Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling.

Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. Research Abstract Details 

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Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. Abstract Text:

Tsuyoshi Morita,Taira Mayanagi,Kenji Sobue,Tsuyoshi Morita,Taira Mayanagi,Kenji Sobue,

Epithelial-mesenchymal transition (EMT) is a critical process occurring during embryonic development and in fibrosis and tumor progression. Dissociation of cell-cell contacts and remodeling of the actin cytoskeleton are major events of the EMT. Here, we show that myocardin-related transcription factors (MRTFs; also known as MAL and MKL) are critical mediators of transforming growth factor beta (TGF-beta) 1-induced EMT. In all epithelial cell lines examined here, TGF-beta1 triggers the nuclear translocation of MRTFs. Ectopic expression of constitutive-active MRTF-A induces EMT, whereas dominant-negative MRTF-A or knockdown of MRTF-A and -B prevents the TGF-beta1-induced EMT. MRTFs form complexes with Smad3. Via Smad3, the MRTF-Smad3 complexes bind to a newly identified cis-element GCCG-like motif in the promoter region of Canis familiaris and the human slug gene, which activates slug transcription and thereby dissociation of cell-cell contacts. MRTFs also increase the expression levels of actin cytoskeletal proteins via serum response factor, thereby triggering reorganization of the actin cytoskeleton. Thus, MRTFs are important mediators of TGF-beta1-induced EMT.

Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. Publishing Authors By Initials

T Morita,T Mayanagi,K Sobue,T Morita,T Mayanagi,K Sobue,

For similar enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins research abstracts see: enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins research

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Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of cell biology

VOLUME: 179

Page Numbers: 1027-42

Journal Abbreviation: J. Cell Biol.

ISSN: 1540-8140

DAY: 3

MONTH: Dec

YEAR: 2007

Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. Information

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LANGUAGE: eng

NlmUniqueID: 375356

Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. Keywords Mesh Terms:

KEYWORDS: rho GTP-Binding Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling. Information

Substance Name: rho GTP-Binding Proteins

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling.

AFFILIATION: Department of Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

Country: United States

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MEDLINETA: J Cell Biol

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