Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation.

Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Research Abstract Details 

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Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Abstract Text:

Chanhee Kang,Young-jai You,Leon Avery,

Autophagy is a major pathway used to degrade long-lived proteins and organelles. Autophagy is thought to promote both cell and organism survival by providing fundamental building blocks to maintain energy homeostasis during starvation. Under different conditions, however, autophagy may instead act to promote cell death through an autophagic cell death pathway distinct from apoptosis. Although several recent papers suggest that autophagy plays a role in cell death, it is not known whether autophagy can cause the death of an organism. Furthermore, why autophagy acts in some instances to promote survival but in others to promote death is poorly understood. Here we show that physiological levels of autophagy act to promote survival in Caenorhabditis elegans during starvation, whereas insufficient or excessive levels of autophagy contribute to death. We found that inhibition of autophagy decreases survival of wild-type worms during starvation, and that muscarinic signaling regulates starvation-induced autophagy, at least in part, through the death-associated protein kinase signaling pathway. Furthermore, we found that in gpb-2 mutants, in which muscarinic signaling cannot be down-regulated, starvation induces excessive autophagy in pharyngeal muscles, which in turn, causes damage that may contribute to death. Taken together, our results demonstrate that autophagy can have either prosurvival or prodeath functions in an organism, depending on its level of activation.

Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Publishing Authors By Initials

C Kang,YJ You,L Avery,

For similar human activities: survival research abstracts see: human activities: survival research

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Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genes & development

VOLUME: 21

Page Numbers: 2161-71

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 1

MONTH: Sep

YEAR: 2007

Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711660

Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Keywords Mesh Terms:

KEYWORDS: Survival

MESH TERMS: mortality

Chemical & Substance for Abstract: Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Information

Substance Name: bec-1 protein, C elegans

Registry Number: 0

Grant and Affiliation Information for Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation.

AFFILIATION: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Chanhee.Kang@UTSouthwestern.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL46154

ACRONYM: HL

MEDLINETA: Genes Dev

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