Dual localization: proteins in extracellular and intracellular compartments.

Dual localization: proteins in extracellular and intracellular compartments. Research Abstract Details 

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Dual localization: proteins in extracellular and intracellular compartments. Abstract Text:

Eric J Arnoys,John L Wang,

The goal of this article is to provide a comprehensive catalog of those proteins documented to exhibit dual localization, being found in both the extracellular compartment (cell surface and extracellular medium) as well as the intracellular compartment (cytosol and nucleus). A large subset of these proteins that show dual localization is found both in the nucleus and outside of cells. Proteins destined to be secreted out of the cell or to be expressed at the cell surface usually enter the endomembrane pathway on the basis of a signal sequence that targets them into the endoplasmic reticulum. Proteins destined for import into the nucleus, on the other hand, usually carry a nuclear localization signal. We have organized our catalog in terms of the presence and absence of these trafficking signals: (a) proteins that contain a signal sequence but no nuclear localization signal; (b) proteins that contain both a signal sequence as well as a nuclear localization signal; (c) proteins that contain a nuclear localization signal but lack a signal sequence; and (d) proteins containing neither a signal sequence nor a nuclear localization signal. Novel insights regarding the activities of several classes of proteins exhibiting dual localization can be derived when one targeting signal is experimentally abrogated. For example, the mitogenic activity of both fibroblasts growth factor-1 and schwannoma-derived growth factor clearly requires nuclear localization, independent of the activation of the receptor tyrosine kinase signaling pathway. In addition, there is a growing list of integral membrane receptors that undergo translocation to the nucleus, with bona fide nuclear localization signals and transcription activation activity. The information provided in this descriptive catalog will, hopefully, stimulate investigations into the pathways and mechanisms of transport between these compartments and the physiological significance of dual localization.

Dual localization: proteins in extracellular and intracellular compartments. Publishing Authors By Initials

EJ Arnoys,JL Wang,

For similar proteins research abstracts see: proteins research

PUBMED ID PMID:

MEDLINE DATE:

Dual localization: proteins in extracellular and intracellular compartments. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta histochemica

VOLUME: 109

Page Numbers: 89-110

Journal Abbreviation: Acta Histochem.

ISSN: 0065-1281

DAY: 25

MONTH: 01

YEAR: 2007

Dual localization: proteins in extracellular and intracellular compartments. Information

Number of References: 236

LANGUAGE: eng

NlmUniqueID: 370320

Dual localization: proteins in extracellular and intracellular compartments. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Dual localization: proteins in extracellular and intracellular compartments. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for Dual localization: proteins in extracellular and intracellular compartments.

AFFILIATION: Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, MI 49546, USA.

Country: Germany

AGENCY: United States PHS

GRANT: RM-38740

ACRONYM:

MEDLINETA: Acta Histochem

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