Dual function of Sox1 in telencephalic progenitor cells.

Dual function of Sox1 in telencephalic progenitor cells. Research Abstract Details 

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Dual function of Sox1 in telencephalic progenitor cells. Abstract Text:

Lixin Kan,Ali Jalali,Li-Ru Zhao,Xiaojing Zhou,Tammy McGuire,Ilias Kazanis,Vasso Episkopou,Alexander G Bassuk,John A Kessler,Lixin Kan,Ali Jalali,Li-Ru Zhao,Xiaojing Zhou,Tammy McGuire,Ilias Kazanis,Vasso Episkopou,Alexander G Bassuk,John A Kessler,

The transcription factor, Sox1 has been implicated in the maintenance of neural progenitor cell status, but accumulating evidence suggests that this is only part of its function. This study examined the role of Sox1 expression in proliferation, lineage commitment, and differentiation by telencephalic neural progenitor cells in vitro and in vivo, and further clarified the pattern of Sox1 expression in postnatal and adult mouse brain. Telencephalic neural progenitor cells isolated from Sox1 null embryos formed neurospheres normally, but were specifically deficient in neuronal differentiation. Conversely, overexpression of Sox1 in the embryonic telencephalon in vivo both expanded the progenitor pool and biased neural progenitor cells towards neuronal lineage commitment. Sox1 mRNA and protein were found to be persistently expressed in the postnatal and adult brain in both differentiated and neurogenic regions. Importantly, in differentiated regions Sox1 co-labeled only with neuronal markers. These observations, coupled with previous studies, suggest that Sox1 expression by early embryonic progenitor cells initially helps to maintain the cells in cell cycle, but that continued expression subsequently promotes neuronal lineage commitment.

Dual function of Sox1 in telencephalic progenitor cells. Publishing Authors By Initials

L Kan,A Jalali,LR Zhao,X Zhou,T McGuire,I Kazanis,V Episkopou,AG Bassuk,JA Kessler,L Kan,A Jalali,LR Zhao,X Zhou,T McGuire,I Kazanis,V Episkopou,AG Bassuk,JA Kessler,

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Dual function of Sox1 in telencephalic progenitor cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Developmental biology

VOLUME: 310

Page Numbers: 85-98

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 27

MONTH: 07

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 372762

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Grant and Affiliation Information for Dual function of Sox1 in telencephalic progenitor cells.

AFFILIATION: Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward 10-233, Chicago, IL 60611-3008, USA. l-kan@northwestern.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS51962

ACRONYM: NS

MEDLINETA: Dev Biol

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