Drug transporters as targets for cancer chemotherapy.

Drug transporters as targets for cancer chemotherapy. Research Abstract Details 

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Drug transporters as targets for cancer chemotherapy. Abstract Text:

Takeo Nakanishi,

Transporter proteins play an important role in taking up nutrients into and effluxing xenobiotics out of cells to sustain cell survival. Transporters that affect drug absorption, distribution and excretion are the so-called drug transporters. In the last decade, a number of studies revealed interactions between drug transporters and clinically important anticancer agents. Utilizing the knowledge of transporter functions offers us the possibility of delivering a drug to the target tissues, avoiding distribution to other tissues and improving oral bioavailability. Many transporters have been reported to be differentially up-regulated in cancer cells compared to normal tissues, suggesting that the differential expression of transporters in cancer cells may provide good targets for enhancing drug delivery as well as diagnostic markers for cancer therapy. This review will focus on the role of drug transporters in the adaptation and growth of tumors and in their potential usefulness as therapeutic targets in cancer.

Drug transporters as targets for cancer chemotherapy. Publishing Authors By Initials

T Nakanishi,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

PUBMED ID PMID:

MEDLINE DATE: 2007 May-Jun

Drug transporters as targets for cancer chemotherapy. Journal Published:

PUBLICATION TYPE: Review

Journal: Cancer genomics & proteomics

VOLUME: 4

Page Numbers: 241-54

Journal Abbreviation:

ISSN: 1109-6535

DAY: 28

MONTH: 11

YEAR: 2007

Drug transporters as targets for cancer chemotherapy. Information

Number of References: 98

LANGUAGE: eng

NlmUniqueID: 101188791

Drug transporters as targets for cancer chemotherapy. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: drug effects

Chemical & Substance for Abstract: Drug transporters as targets for cancer chemotherapy. Information

Substance Name: Tumor Markers, Biological

Registry Number: 0

Grant and Affiliation Information for Drug transporters as targets for cancer chemotherapy.

AFFILIATION: The Program in Experimental Therapeutics, Marlene and Stewart Greenebaum Cancer Center, School of Medicine, University of Maryland at Baltimore, Baltimore, MD 21201, USA. tnakanishi@som.umaryland.edu

Country: Greece

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MEDLINETA: Cancer Genomics Proteomics

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