Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport.

Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport. Research Abstract Details 

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Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport. Abstract Text:

This is part II of a review on the transport of drugs across the blood-brain barrier. In this part, the emphasis is on the various experimental techniques that can be used to characterize the blood-brain barrier transport of drugs. Generally speaking, three approaches can be distinguished: in vitro techniques using isolated brain capillaries, cerebrovascular endothelial cells in primary culture or endothelium-derived cell lines; in vivo techniques (both single-passage and multi-passage techniques) and in situ perfusion techniques. Each of these techniques has specific advantages and disadvantages associated with it. Therefore, in many instances, a combination of different approaches is needed to study the fundamental aspects of drug transport across the blood-brain barrier.

Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport. Publishing Authors By Initials

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Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport. Journal Published:

PUBLICATION TYPE: Review

Journal: Pharmaceutisch weekblad. Scientific edition

VOLUME: 14

Page Numbers: 338-48

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ISSN: 0167-6555

DAY: 11

MONTH: Dec

YEAR: 1992

Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport. Information

Number of References: 57

LANGUAGE: eng

NlmUniqueID: 7907992

Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport. Keywords Mesh Terms:

KEYWORDS: Pharmaceutical Preparations

MESH TERMS: metabolism

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Substance Name: Pharmaceutical Preparations

Registry Number: 0

Grant and Affiliation Information for Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport.

AFFILIATION: Centre for Bio-Pharmaceutical Sciences, Leiden University, Sylvius Laboratories, The Netherlands.

Country: NETHERLANDS

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MEDLINETA: Pharm Weekbl Sci

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