Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects.

Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects. Research Abstract Details 

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Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects. Abstract Text:

This review describes various aspects of the transport of drugs across the blood-brain barrier and comprises three parts. In this first part, the anatomical and physiological aspects of blood-brain transport are discussed. It appears that the blood-brain barrier has an anatomical basis at the endothelium of the capillary wall. This endothelium is characterized by the presence of very tight junctions. As a result, the transport by passive diffusion of drugs with a low lipophilicity, is restricted. For certain classes of closely related relatively hydrophilic compounds, however, the presence of specialized carrier systems has been demonstrated which may facilitate transport. Also evidence is presently available, that the permeability of the blood-brain barrier may be under active regulatory control. It is expected that improved knowledge of the anatomical and physiological aspects of the blood-brain barrier and its regulation will provide a scientific basis for the development of strategies to improve the transport of drugs into the central nervous system.

Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects. Publishing Authors By Initials

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Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects. Journal Published:

PUBLICATION TYPE: Review

Journal: Pharmaceutisch weekblad. Scientific edition

VOLUME: 14

Page Numbers: 305-10

Journal Abbreviation:

ISSN: 0167-6555

DAY: 16

MONTH: Oct

YEAR: 1992

Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects. Information

Number of References: 51

LANGUAGE: eng

NlmUniqueID: 7907992

Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects. Keywords Mesh Terms:

KEYWORDS: Pharmaceutical Preparations

MESH TERMS: metabolism

Chemical & Substance for Abstract: Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects. Information

Substance Name: Pharmaceutical Preparations

Registry Number: 0

Grant and Affiliation Information for Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects.

AFFILIATION: Center for Bio-Pharmaceutical Sciences, University of Leiden, Sylvius Laboratories, The Netherlands.

Country: NETHERLANDS

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MEDLINETA: Pharm Weekbl Sci

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