Drug-metabolizing cytochrome P450s in the brain.

Drug-metabolizing cytochrome P450s in the brain. Research Abstract Details 

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Drug-metabolizing cytochrome P450s in the brain. Abstract Text:

Most CYP subfamilies have been identified in brain, but there is much more information available on the distribution and metabolic activity of CYP subfamilies in brain of rodents than in humans, and what we do know still lags far behind our knowledge of hepatic CYPs. With the constant acquisition of data on the genetics, molecular structure and metabolic capacity of brain CYPs, we are increasingly able to investigate their role in the brain and the possible consequences of altered local metabolism. However, at this stage, the contribution of brain CYPs to local metabolism of drugs, toxins and endogenous compounds is still speculative, as is the role for these CYPs in modulating brain function and in the development of brain diseases. Much investigative work remains to be done to firmly establish the links between the presence of CYPs in brain, their function in this highly heterogeneous and complex organ and the consequences on overall brain function and health.

Drug-metabolizing cytochrome P450s in the brain. Publishing Authors By Initials

For similar polycyclic compounds: steroids research abstracts see: polycyclic compounds: steroids research

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Drug-metabolizing cytochrome P450s in the brain. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of psychiatry & neuroscience : JPN

VOLUME: 27

Page Numbers: 406-15

Journal Abbreviation: J Psychiatry Neurosci

ISSN: 1180-4882

DAY: 6

MONTH: Nov

YEAR: 2002

Drug-metabolizing cytochrome P450s in the brain. Information

Number of References: 165

LANGUAGE: eng

NlmUniqueID: 9107859

Drug-metabolizing cytochrome P450s in the brain. Keywords Mesh Terms:

KEYWORDS: Steroids

MESH TERMS: metabolism

Chemical & Substance for Abstract: Drug-metabolizing cytochrome P450s in the brain. Information

Substance Name: Cytochrome P-450 Enzyme System

Registry Number: 9035-51-2

Grant and Affiliation Information for Drug-metabolizing cytochrome P450s in the brain.

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Country: Canada

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MEDLINETA: J Psychiatry Neurosci

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