Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease.

Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease. Research Abstract Details 

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Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease. Abstract Text:

Marc N Potenza,Valerie Voon,Daniel Weintraub,Marc N Potenza,Valerie Voon,Daniel Weintraub,

Impulse control disorders (ICDs) constitute a group of relatively common psychiatric conditions. ICDs typically involve pleasurable or hedonic behaviors (e.g. gambling, shopping or sex) that are performed repetitively, excessively or compulsively, to an extent that interferes in major areas of life functioning. Over the past decade, case reports, case studies and controlled examinations have reported ICDs in neurological patients, particularly those with Parkinson's disease (PD). A relationship between dopamine agonist treatment and ICDs was initially suggested on the basis of clinical observations, and subsequent systematic studies have provided more-substantial support for this association. Ongoing studies of the clinical characteristics of individuals with PD with and without ICDs suggest that certain individuals might be at increased risk of developing ICDs during PD treatment. Emerging data suggest that the association between dopamine agonists and ICDs extends into other neurological patient populations in which these agents are employed, such as those with restless legs syndrome. In this article, we summarize current knowledge regarding ICDs, review their relationships with PD and its treatments, provide practical clinical recommendations based on existing data, and suggest avenues for future research directed at advancing clinical care strategies.

Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease. Publishing Authors By Initials

MN Potenza,V Voon,D Weintraub,MN Potenza,V Voon,D Weintraub,

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Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nature clinical practice. Neurology

VOLUME: 3

Page Numbers: 664-72

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ISSN: 1745-8358

DAY: 29

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA. marc.potenza@yale.edu

Country: England

AGENCY: United States NIDA

GRANT: R01-DA019039

ACRONYM: DA

MEDLINETA: Nat Clin Pract Neurol

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