Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient.

Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient. Research Abstract Details 

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Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient. Abstract Text:

Taio Naniwa,Shinji Maeda,Hiroo Sawada,Yuko Watanabe,Tomoyo Osawa,Yoshihito Hayami,Shogo Banno,Akimichi Morita,Ryuzo Ueda,

BACKGROUND: Drug-induced hypersensitivity syndrome (DIHS) is characterized by a severe multiorgan hypersensitivity reaction that usually appears after prolonged exposure to certain drugs and may be related to reactivation of herpes viruses. There have been few reports regarding the clinical association of DIHS with pathogens other than herpes viruses. CASE SUMMARY: We report a case of scleroderma with DIHS associated with paramyxovirus infection. A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim. The diagnosis of DIHS was made based on the patient's history of using an offending drug, clinical manifestations and laboratory data showing peripheral eosinophilia with the presence of atypical lymphocytes. Virological tests showed significant increases of antibody titers against mumps virus and parainfluenza virus type 2, which strongly suggested that paramyxovirus infection occurred during the clinical course of DIHS. DISCUSSION: These findings suggest that paramyxovirus infection had contributed to the development of DIHS in this patient and that there is a need to seek evidence of other viral infections in some cases of DIHS, especially those without herpes virus reactivation/infection.

Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient. Publishing Authors By Initials

T Naniwa,S Maeda,H Sawada,Y Watanabe,T Osawa,Y Hayami,S Banno,A Morita,R Ueda,

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Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Allergology international : official journal of th

VOLUME: 56

Page Numbers: 303-8

Journal Abbreviation:

ISSN: 1323-8930

DAY: 1

MONTH: 06

YEAR: 2007

Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9616296

Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient. Keywords Mesh Terms:

KEYWORDS: Trimethoprim-Sulfamethoxazole Combinatio

MESH TERMS: immunology

Chemical & Substance for Abstract: Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient. Information

Substance Name: Methylprednisolone

Registry Number: 83-43-2

Grant and Affiliation Information for Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient.

AFFILIATION: Division of Rheumatology, Department of Internal Medicine and Molecular Science, Aichi, Japan. tnaniwa@med.nagoya-cu.ac.jp

Country: Japan

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MEDLINETA: Allergol Int

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