Drug delivery system of hepatocyte growth factor for the treatment of vocal fold scarring in a canine model.

Drug delivery system of hepatocyte growth factor for the treatment of vocal fold scarring in a canine model. Research Abstract Details 

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Drug delivery system of hepatocyte growth factor for the treatment of vocal fold scarring in a canine model. Abstract Text:

Tsunehisa Ohno,Shigeru Hirano,Shin-ichi Kanemaru,Masaru Yamashita,Hiroo Umeda,Atsushi Suehiro,Yoshihiro Tamura,Tatsuo Nakamura,Juichi Ito,Yasuhiko Tabata,

OBJECTIVES: Vocal fold scarring remains a therapeutic challenge. Previous studies have indicated that hepatocyte growth factor (HGF), a strong antifibrotic element, has therapeutic potential for restoring scarred vocal folds. To enhance the effect of HGF in vivo, we developed a novel drug delivery system (DDS) in which HGF is embedded in gelatin hydrogel and continuously released over a period of 2 weeks. In the present study we investigated the therapeutic efficacy of the HGF DDS on vocal fold scarring by using a canine model. METHODS: The vocal folds of 8 beagles were unilaterally scarred by stripping the entire layer of the lamina propria. The contralateral vocal folds were kept intact as normal controls. One month after the procedure, hydrogels (0.5 mL) containing 1 microg of HGF were injected into the scarred vocal folds of 4 dogs (HGF-treated group), whereas hydrogels containing saline solution were injected in the other 4 dogs (sham group). Histologic and vibratory examinations were completed for each group 6 months after the initial surgery. RESULTS: The excised larynx experiments showed significantly better vibration in terms of mucosal wave amplitude and glottal closure in the HGF-treated group compared to the sham group. Histologic evaluation of the vocal folds indicated remarkable reduction in collagen deposition and tissue contraction, with favorable restoration of hyaluronic acid and elastin in the HGF-treated group. CONCLUSIONS: The present findings suggest that the novel HGF DDS may provide favorable effects in restoring the vibratory properties of scarred vocal folds.

Drug delivery system of hepatocyte growth factor for the treatment of vocal fold scarring in a canine model. Publishing Authors By Initials

T Ohno,S Hirano,S Kanemaru,M Yamashita,H Umeda,A Suehiro,Y Tamura,T Nakamura,J Ito,Y Tabata,

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Drug delivery system of hepatocyte growth factor for the treatment of vocal fold scarring in a canine model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Annals of otology, rhinology, and laryngology

VOLUME: 116

Page Numbers: 762-9

Journal Abbreviation: Ann. Otol. Rhinol. Laryngol.

ISSN: 0003-4894

DAY: 29

MONTH: Oct

YEAR: 2007

Drug delivery system of hepatocyte growth factor for the treatment of vocal fold scarring in a canine model. Information

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LANGUAGE: eng

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AFFILIATION: Dept of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, 54, Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

Country: United States

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MEDLINETA: Ann Otol Rhinol Laryngol

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