Drug-associated hospital admissions in older medical patients.

Drug-associated hospital admissions in older medical patients. Research Abstract Details 

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Drug-associated hospital admissions in older medical patients. Abstract Text:

A survey of drug-related admissions of patients aged 50 years and older was conducted at the Health Sciences Centre, Winnipeg to determine the interrelationship of risk factors, and isolate the effect of age. All nonelective medical admissions were prospectively assessed to determine the role of drug therapy as a contributory factor. Of the 863 eligible admissions, 162 exhibited at least one drug-related adverse patient event (DRAPE) at the time of hospitalization. This accounted for 19% of the admissions (23% of 718 admissions that involved prescription drugs). Although adverse drug reactions were responsible for many DRAPEs (48%), intentional noncompliance (27%), treatment failure (19%), alcohol (14%), and medication error (10%) were also frequent contributing causes. Drugs commonly implicated in DRAPEs were systemic steroids, digoxin, nonsteroidal anti-inflammatory agents, alpha-methyldopa, calcium channel blockers, beta-blockers, theophylline, furosemide, sympathomimetics, thiazides, and benzodiazepines. The risk of a DRAPE was related to the number of diseases prior to admission (r = 0.81; P less than .026) and the number of drugs used (r = 0.77; P less than .001). Age was not correlated with the risk of a DRAPE. Females had significantly more adverse drug reactions, although sex was not a predictor for overall DRAPE risk.

Drug-associated hospital admissions in older medical patients. Publishing Authors By Initials

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Drug-associated hospital admissions in older medical patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Geriatrics Society

VOLUME: 36

Page Numbers: 1092-8

Journal Abbreviation: J Am Geriatr Soc

ISSN: 0002-8614

DAY: 10

MONTH: Dec

YEAR: 1988

Drug-associated hospital admissions in older medical patients. Information

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LANGUAGE: eng

NlmUniqueID: 7503062

Drug-associated hospital admissions in older medical patients. Keywords Mesh Terms:

KEYWORDS: Pharmaceutical Preparations

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Drug-associated hospital admissions in older medical patients. Information

Substance Name: Pharmaceutical Preparations

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Grant and Affiliation Information for Drug-associated hospital admissions in older medical patients.

AFFILIATION: Department of Medicine, Faculty of Medicine, University of Manitoba, Canada.

Country: UNITED STATES

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MEDLINETA: J Am Geriatr Soc

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