Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus.

Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Abstract Text:

Yuzhong Cheng,Howard A Nash,Yuzhong Cheng,Howard A Nash,

In both vertebrates and invertebrates, ion channels of the TRP superfamily are known to be influenced by a variety of accessory factors, but the list of interacting proteins is acknowledged to be incomplete. Although previous work showed that Drosophila TRP function is disrupted by mutations in the inaF locus, the mechanism of this effect has remained obscure. Here we show that a previously overlooked small protein, INAF-B, is encoded by the locus and fulfills its critical role in retinal physiology. The 81-aa INAF-B gene product is an integral membrane protein that colocalizes to rhabdomeres along with TRP channels. Immunoprecipitation experiments demonstrate that the two proteins participate in a complex, and blotting experiments show that neither protein survives in the absence of the other. Both proteins are normally part of a large supramolecular assembly, the signalplex, but their interaction persists even in the absence of the scaffold for this structure. The inaF locus encodes three other proteins, each of which has diverged from INAF-B except for a 32-aa block of residues that encompasses a transmembrane domain. This conserved sequence defines an inaF motif, representatives of which are found in proteins from organisms as diverse as nematodes, fish, and humans. Given the role of INAF-B, these proteins are good candidates for interacting partners of other members of the TRP superfamily.

Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Publishing Authors By Initials

Y Cheng,HA Nash,Y Cheng,HA Nash,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 17730-4

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 29

MONTH: 10

YEAR: 2007

Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus.

AFFILIATION: Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus Related Publications

• A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia.
• Analysis of leukocyte migration through monolayers of cultured endothelial cells.
• Application of ICP-MS as a Multi-Element Detector for Sulfur and Metal Hydride Impurities in Hydrocarbon Matrices.
• Application of XML Database Technology to Biological Pathway Datasets.
• Closure of temporary stoma after anterior resection.
• Comparative genomic analysis of Campylobacter jejuni associated with Guillain-Barré and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of genomic similarity.
• Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response.
• Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus.
• Finite Element Modelling of Breast Biomechanics: Finding a Reference aState.
• Finite element modelling of breast biomechanics: directly calculating the reference state.
• Frictional contact mechanics methods for soft materials: Application to tracking breast cancers.
• GTN headaches and reduction of natural banding?
• How and why do we measure surgical risk?
• Ideological and personal zeal reactions to threat among people with high self-esteem: motivated promotion focus.
• Leprosaria--a continuing social challenge.
• Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment.
• Ontology-based aggregation of biological pathway datasets.
• Open repair does not equate to Lichtenstein.
• Radiographic evidence of intermittent protrusion of an intervertebral disc; case report.
• Should indeterminate lung lesions reported on staging CT scans influence the management of patients with colorectal cancer?
• Stability of benzoyl peroxide in aromatic ester-containing topical formulations.
• Studying bacterial genome dynamics using microarray-based comparative genomic hybridization.
• The Relationship Between Television Advertising, Children's Viewing and Their Requests to Father Christmas.
• The Tennessee four quarter plan after 18 years.
• The climacteric syndrome.
• The effect of beta-halogenated ethylamine derivatives on ventricular fibrillation and on the isolated heart.
• The future of disease management. Interview by Ian Morrison.
• Tissue factor (TF) and vascular endothelial growth factor (VEGF) expression in colorectal cancer: relation with cancer recurrence.
• Towards tracking breast cancer across medical images using subject-specific biomechanical models.
• Weight changes and sex incidence of tuberculosis.