Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan.

Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Research Abstract Details 

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Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Abstract Text:

Lisa Connell-Crowley,Duc Vo,Lori Luke,Edward Giniger,

The cyclin-dependent kinase Cdk5 has attracted a great deal of attention both because of its roles in cell migration and axon patterning, and the extensive data implicating it in adult-onset neurodegeneration in mammals. Both the kinase activity and the biological effects of Cdk5 are absolutely dependent on association with an activating subunit, called p35. We show here that Drosophila lacking the Cdk5 activator, D-p35, display a wide range of defects in embryonic axon patterning. We further show that, while viable and fertile, p35 mutant adults display progressive, age-dependent loss of motor function and have a significantly shortened lifespan.

Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Publishing Authors By Initials

L Connell-Crowley,D Vo,L Luke,E Giniger,

For similar proteins: nerve tissue proteins research abstracts see: proteins: nerve tissue proteins research

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Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Mechanisms of development

VOLUME: 124

Page Numbers: 341-9

Journal Abbreviation: Mech. Dev.

ISSN: 0925-4773

DAY: 15

MONTH: 02

YEAR: 2007

Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Information

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LANGUAGE: eng

NlmUniqueID: 9101218

Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Keywords Mesh Terms:

KEYWORDS: Nerve Tissue Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Information

Substance Name: Cyclin-Dependent Kinase 5

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan.

AFFILIATION: Basic Neuroscience Program, National Institute of Neurological Disorders and Stroke (NINDS), National Human Genome Research Institute (NHGRI), National Institutes of Health Bldg 37, Rm 1016, 37 Convent Drive, Bethesda, MD 20892, USA.

Country: Ireland

AGENCY: United States NINDS

GRANT: Z01 NS003013-02

ACRONYM: NS

MEDLINETA: Mech Dev

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