Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl.

Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Research Abstract Details 

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Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Abstract Text:

Douglas A Harrison,Douglas A Harrison,

X-linked signal elements (XSEs) communicate the dose of X chromosomes to the regulatory-switch gene Sex-lethal (Sxl) during Drosophila sex determination. Unequal XSE expression in precellular XX and XY nuclei ensures that only XX embryos will activate the establishment promoter, SxlPe, to produce a pulse of the RNA-binding protein, SXL [1]. Once XSE protein concentrations have been assessed, SxlPe is inactivated and the maintenance promoter, SxlPm, is turned on in both sexes; however, only in females is SXL present to direct the SxlPm-derived transcripts to be spliced into functional mRNA [2, 3]. Thereafter, Sxl is maintained in the on state by positive autoregulatory RNA splicing [2]. Once set in the stable on (female) or off (male) state, Sxl controls somatic sexual development through control of downstream effectors of sexual differentiation and dosage compensation [1, 4]. Most XSEs encode transcription factors that bind SxlPe, but the XSE unpaired (upd) encodes a secreted ligand for the JAK/STAT pathway [5-7]. We show that although STAT directly regulates SxlPe, it is dispensable for promoter activation. Instead, JAK/STAT is needed to maintain high-level SxlPe expression in order to ensure Sxl autoregulation in XX embryos. Thus, upd is a unique XSE that augments, rather than defines, the initial sex-determination signal.

Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Publishing Authors By Initials

DA Harrison,DA Harrison,

For similar cells: cellular structures: chromosomes: sex chromosomes: x chromosome research abstracts see: cells: cellular structures: chromosomes: sex chromosomes: x chromosome research

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Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Current biology : CB

VOLUME: 17

Page Numbers: 643-8

Journal Abbreviation: Curr. Biol.

ISSN: 0960-9822

DAY: 15

MONTH: 03

YEAR: 2007

Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Information

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LANGUAGE: eng

NlmUniqueID: 9107782

Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Keywords Mesh Terms:

KEYWORDS: X Chromosome

MESH TERMS: metabolism

Chemical & Substance for Abstract: Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Information

Substance Name: hop protein, Drosophila

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl.

AFFILIATION: Department of Biology, Texas A&M University, 3258 TAMU, College Station, TX 77843, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM063606

ACRONYM: GM

MEDLINETA: Curr Biol

REFSOURCE: Curr Biol. 2007 May 1;17(9):R328-30

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