Drosophila cbl Is Essential for Control of Cell Death and Cell Differentiation during Eye Development.

Drosophila cbl Is Essential for Control of Cell Death and Cell Differentiation during Eye Development. Research Abstract Details 

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Drosophila cbl Is Essential for Control of Cell Death and Cell Differentiation during Eye Development. Abstract Text:

Yuan Wang,Christian Werz,Dongbin Xu,Zhihong Chen,Ying Li,Ernst Hafen,Andreas Bergmann,Yuan Wang,Christian Werz,Dongbin Xu,Zhihong Chen,Ying Li,Ernst Hafen,Andreas Bergmann,

BACKGROUND: Activation of cell surface receptors transduces extracellular signals into cellular responses such as proliferation, differentiation and survival. However, as important as the activation of these receptors is their appropriate spatial and temporal down-regulation for normal development and tissue homeostasis. The Cbl family of E3-ubiquitin ligases plays a major role for the ligand-dependent inactivation of receptor tyrosine kinases (RTKs), most notably the Epidermal Growth Factor Receptor (EGFR) through ubiquitin-mediated endocytosis and lysosomal degradation. METHODOLOGY/PRINCIPAL FINDINGS: Here, we report the mutant phenotypes of Drosophila cbl (D-cbl) during eye development. D-cbl mutants display overgrowth, inhibition of apoptosis, differentiation defects and increased ommatidial spacing. Using genetic interaction and molecular markers, we show that most of these phenotypes are caused by increased activity of the Drosophila EGFR. Our genetic data also indicate a critical role of ubiquitination for D-cbl function, consistent with biochemical models. CONCLUSIONS/SIGNIFICANCE: These data may provide a mechanistic model for the understanding of the oncogenic activity of mammalian cbl genes.

Drosophila cbl Is Essential for Control of Cell Death and Cell Differentiation during Eye Development. Publishing Authors By Initials

Y Wang,C Werz,D Xu,Z Chen,Y Li,E Hafen,A Bergmann,Y Wang,C Werz,D Xu,Z Chen,Y Li,E Hafen,A Bergmann,

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Drosophila cbl Is Essential for Control of Cell Death and Cell Differentiation during Eye Development. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: PLoS ONE

VOLUME: 3

Page Numbers: e1447

Journal Abbreviation: PLoS ONE

ISSN: 1932-6203

DAY: 16

MONTH: 01

YEAR: 2008

Drosophila cbl Is Essential for Control of Cell Death and Cell Differentiation during Eye Development. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Drosophila cbl Is Essential for Control of Cell Death and Cell Differentiation during Eye Development.

AFFILIATION: Department of Biochemistry and Molecular Biology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, United States of America.

Country: United States

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MEDLINETA: PLoS ONE

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