Drosophila C-type lectins enhance cellular encapsulation.

Drosophila C-type lectins enhance cellular encapsulation. Research Abstract Details 

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Drosophila C-type lectins enhance cellular encapsulation. Abstract Text:

Jingqun Ao,Erjun Ling,Xiao-Qiang Yu,

C-type lectins are calcium-dependent carbohydrate binding proteins, and animal C-type lectins participate in innate immunity and cell-cell interactions. In the fruit fly Drosophila melanogaster, more than 30 genes encode C-type lectin domains. However, functions of Drosophila C-type lectins in innate immunity are not well understood. This study is to investigate whether two Drosophila C-type lectins, CG33532 and CG33533 (designated as DL2 and DL3, respectively), are involved in innate immune responses. Recombinant DL2 and DL3 were expressed and purified. Both DL2 and DL3 agglutinated Gram-negative Escherichia coli in a calcium-dependent manner. Though DL2 and DL3 are predicted to be secreted proteins, they were detected on the surface of Drosophila hemocytes, and recombinant DL2 and DL3 also directly bound to hemocytes. Coating of agarose beads with recombinant DL2 and DL3 enhanced their encapsulation and melanization by Drosophila hemocytes in vitro. However, hemocyte encapsulation was blocked when the lectin-coated beads were pre-incubated with rat polyclonal antibody specific for DL2 or DL3. Our results suggest that DL2 and DL3 may act as pattern recognition receptors to mediate hemocyte encapsulation and melanization by directly recruiting hemocytes to the lectin-coated surface.

Drosophila C-type lectins enhance cellular encapsulation. Publishing Authors By Initials

J Ao,E Ling,XQ Yu,

For similar proteins: recombinant proteins research abstracts see: proteins: recombinant proteins research

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Drosophila C-type lectins enhance cellular encapsulation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular immunology

VOLUME: 44

Page Numbers: 2541-8

Journal Abbreviation: Mol. Immunol.

ISSN: 0161-5890

DAY: 6

MONTH: 02

YEAR: 2007

Drosophila C-type lectins enhance cellular encapsulation. Information

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LANGUAGE: eng

NlmUniqueID: 7905289

Drosophila C-type lectins enhance cellular encapsulation. Keywords Mesh Terms:

KEYWORDS: Recombinant Proteins

MESH TERMS: immunology

Chemical & Substance for Abstract: Drosophila C-type lectins enhance cellular encapsulation. Information

Substance Name: Recombinant Proteins

Registry Number: 0

Grant and Affiliation Information for Drosophila C-type lectins enhance cellular encapsulation.

AFFILIATION: Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110, USA.

Country: England

AGENCY: United States NIGMS

GRANT: R01 GM066356-06

ACRONYM: GM

MEDLINETA: Mol Immunol

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