DR5 Activation of Caspase-8 Induces DC Maturation and Immune Enhancement In Vivo.

DR5 Activation of Caspase-8 Induces DC Maturation and Immune Enhancement In Vivo. Research Abstract Details 

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DR5 Activation of Caspase-8 Induces DC Maturation and Immune Enhancement In Vivo. Abstract Text:

Michael A Chattergoon,Karuppiah Muthumani,Yutaka Tamura,Mathura Ramanathan,Jason P Shames,Vera Saulino,Tara M Robinson,Luis J Montaner,David B Weiner,

Non-homeostatic tissue apoptosis in vivo has been shown to induce inflammatory responses and facilitate the cross-presentation of proteins within apoptotic bodies. We hypothesize that in the presence of foreign antigens, the apoptotic-inflammatory process improves immune priming; further, molecules that trigger apoptosis may be adapted for use as immune adjuvants. One very attractive molecule in this context is the tumor necrosis factor receptor (TNFR) family molecule DR5/TRAIL-receptor 2. We show a significant improvement in CD8(+) T-cell mediated vaccine immunity with the use of death receptor-5 (DR5) as an immune adjuvant, a property that is correlated with the activation of caspases-8 (casp8) and dependent on its ability to induce apoptosis in vivo.Molecular Therapy (2007); 16 2, 419-426. doi:10.1038/sj.mt.6300373.

DR5 Activation of Caspase-8 Induces DC Maturation and Immune Enhancement In Vivo. Publishing Authors By Initials

MA Chattergoon,K Muthumani,Y Tamura,M Ramanathan,JP Shames,V Saulino,TM Robinson,LJ Montaner,DB Weiner,

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DR5 Activation of Caspase-8 Induces DC Maturation and Immune Enhancement In Vivo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular therapy : the journal of the American So

VOLUME: 16

Page Numbers: 419-26

Journal Abbreviation: Mol. Ther.

ISSN: 1525-0016

DAY: 18

MONTH: 12

YEAR: 2007

DR5 Activation of Caspase-8 Induces DC Maturation and Immune Enhancement In Vivo. Information

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LANGUAGE: eng

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AFFILIATION: 1Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Country: United States

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MEDLINETA: Mol Ther

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