Doxorubicin and beta-lapachone release and interaction with micellar core materials: experiment and modeling.

Doxorubicin and beta-lapachone release and interaction with micellar core materials: experiment and modeling. Research Abstract Details 

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Doxorubicin and beta-lapachone release and interaction with micellar core materials: experiment and modeling. Abstract Text:

Damon Sutton,Shihu Wang,Norased Nasongkla,Jinming Gao,Elena E Dormidontova,

Polymer micelles with two different core-forming blocks, poly(d,l -lactide) (PLA) and poly(epsilon-caprolactone) (PCL), but the same coronal material, poly(ethylene glycol) (PEG), were investigated in this study as nanoscopic drug carriers. The release of two different drugs, doxorubicin (DOX) and beta-lapachone (beta-lap), from PEG(5k)-b-PCL(5k) and PEG(5k)-b-PLA(5k) micelles was studied at pH 5.0 and 7.4. Mathematical solutions of both Higuchi's model and Fickian diffusion equations were utilized to elucidate the differences between the micelle core materials for the two drugs. The neutral and smaller of the two drugs tested, beta-lap, demonstrated faster, pH-independent release, suggesting that no substantial changes occurred in either micelle core at lower pH. In contrast, the release rate of DOX was found to noticeably increase at lower pH with a larger cumulative amount of drug released. Different core materials were shown to have considerable influence on the release kinetics of both drugs: in both cases, the more hydrophobic PCL core showed slower drug release rates compared with the less hydrophobic PLA core.

Doxorubicin and beta-lapachone release and interaction with micellar core materials: experiment and modeling. Publishing Authors By Initials

D Sutton,S Wang,N Nasongkla,J Gao,EE Dormidontova,

For similar macromolecular substances: polymers research abstracts see: macromolecular substances: polymers research

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Doxorubicin and beta-lapachone release and interaction with micellar core materials: experiment and modeling. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental biology and medicine (Maywood, N.J.)

VOLUME: 232

Page Numbers: 1090-9

Journal Abbreviation: Exp. Biol. Med. (Maywood)

ISSN: 1535-3702

DAY: 3

MONTH: Sep

YEAR: 2007

Doxorubicin and beta-lapachone release and interaction with micellar core materials: experiment and modeling. Information

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LANGUAGE: eng

NlmUniqueID: 100973463

Doxorubicin and beta-lapachone release and interaction with micellar core materials: experiment and modeling. Keywords Mesh Terms:

KEYWORDS: Polymers

MESH TERMS: chemistry

Chemical & Substance for Abstract: Doxorubicin and beta-lapachone release and interaction with micellar core materials: experiment and modeling. Information

Substance Name: beta-lapachone

Registry Number: 4707-32-8

Grant and Affiliation Information for Doxorubicin and beta-lapachone release and interaction with micellar core materials: experiment and modeling.

AFFILIATION: Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Country: United States

AGENCY: United States NCI

GRANT: R21CA112436

ACRONYM: CA

MEDLINETA: Exp Biol Med (Maywood)

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