Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus.

Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus. Research Abstract Details 

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Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus. Abstract Text:

Joanna Gilbert,Wu Ou,Jonathan Silver,Thomas Benjamin,

Early stages of infection by the mouse polyomavirus have been studied using HeLa cells stably expressing small interfering RNA to protein disulfide isomerase (PDI). Infectibility measured by nuclear T antigen expression was reduced commensurately with the degree of PDI downregulation. Infectibility was restored by transfection with a plasmid expressing PDI but not with a control expressing catalytically inactive enzyme. Deconvolution microscopy using fluorescently labeled virus and cellular markers showed that virus reaches the endoplasmic reticulum (ER) normally in cells with reduced PDI but subsequently fails to exit the ER. Simian virus 40 infection was not inhibited in PDI-downregulated cells. The results are discussed in terms of structural differences between the two viruses and current knowledge of virus disassembly in the ER.

Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus. Publishing Authors By Initials

J Gilbert,W Ou,J Silver,T Benjamin,

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 80

Page Numbers: 10868-70

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 23

MONTH: 08

YEAR: 2006

Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: pathogenicity

Chemical & Substance for Abstract: Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus. Information

Substance Name: Protein Disulfide-Isomerase

Registry Number: EC 5.3.4.1

Grant and Affiliation Information for Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirus.

AFFILIATION: Department of Pathology, NRB-939I, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA-082395

ACRONYM: CA

MEDLINETA: J Virol

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