Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia.

Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. Research Abstract Details 

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Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. Abstract Text:

Yun-Chih Cheng,Hsiupen Lin,Ming-Jer Huang,Jyh-Ming Chow,Shufan Lin,H Eugene Liu,

Valproic acid (VPA), an agent used for neurological disorders, has been shown to be a novel class of histone deacetylase inhibitor (HDACI), able to induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML). In this study, we examined the underlying mechanisms in VPA-mediated activities in AML cells. VPA not only inhibited the growth of HL-60, U937 and NB4 cells by causing cell-cycle arrest at G(0)/G(1) phase and apoptosis, but also induced morphologic and phenotypic changes. VPA markedly increased p21WAF1, and downregulated c-Myc expression at transcriptional levels. Ectopic expression of wildtype c-Myc and T58A mutant significantly inhibited VPA-mediated growth inhibition. As with results from cell line studies, VPA also downregulated c-Myc levels, and induced apoptosis and myeloid differentiation of primary AML cells, leading to decreased colony-forming ability. Given the role of c-Myc in leukemogenesis, our study suggests that VPA might be a potential therapeutic agent for AML.

Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. Publishing Authors By Initials

YC Cheng,H Lin,MJ Huang,JM Chow,S Lin,HE Liu,

For similar organic chemicals: carboxylic acids: acids, acyclic: valerates: pentanoic acids: valproic acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: valerates: pentanoic acids: valproic acid research

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Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Leukemia research

VOLUME: 31

Page Numbers: 1403-11

Journal Abbreviation: Leuk. Res.

ISSN: 0145-2126

DAY: 18

MONTH: 04

YEAR: 2007

Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. Information

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LANGUAGE: eng

NlmUniqueID: 7706787

Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. Keywords Mesh Terms:

KEYWORDS: Valproic Acid

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. Information

Substance Name: Valproic Acid

Registry Number: 99-66-1

Grant and Affiliation Information for Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia.

AFFILIATION: Department of Internal Medicine, Wanfang Hospital-Taipei Medical University, Taipei, Taiwan.

Country: England

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MEDLINETA: Leuk Res

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