Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells.

Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells. Research Abstract Details 

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Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells. Abstract Text:

To understand the effects of the transient ablation of BRCA2 gene expression in dividing human breast cells, we transiently knocked down BRCA2 mRNA in HMEC and other cells. Microarray analysis of mRNAs revealed the down-regulation of the mRNAs of ubiquitin cross-reacting protein (UCRP) and the E2 enzyme that help conjugating UCRP to its target proteins, namely UBE2L6 (UbcH8), in BRCA2 ablated cells. UCRP is an interferon regulated protein, involved in cell growth and cell cycle events by participating in the degradation/modulation of cell cycle regulatory proteins. Quantitative-PCR and Northern analysis confirmed down-regulation of UCRP and UBE2L6 with BRCA2 knockdown, respectively. Since UCRP and UCRPylation have critical roles in the innate immunity against viral infection and during pregnancy, our observation may indicate new roles of the BRCA2 protein.

Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells. Publishing Authors By Initials

For similar proteins: ubiquitins research abstracts see: proteins: ubiquitins research

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Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biochemical and biophysical research communication

VOLUME: 328

Page Numbers: 43-8

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 4

MONTH: Mar

YEAR: 2005

Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells. Information

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LANGUAGE: eng

NlmUniqueID: 372516

Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells. Keywords Mesh Terms:

KEYWORDS: Ubiquitins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells. Information

Substance Name: Ubiquitin-Conjugating Enzymes

Registry Number: EC 6.3.2.19

Grant and Affiliation Information for Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells.

AFFILIATION: Department of Microbiology, Meharry Medical College, Nashville, TN 37208, USA.

Country: United States

AGENCY: United States NCI

GRANT: 1U54CA091408-010003

ACRONYM: CA

MEDLINETA: Biochem Biophys Res Commun

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