Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death.

Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. Research Abstract Details 

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Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. Abstract Text:

Viravuth P Yin,Carl S Thummel,Arash Bashirullah,Viravuth P Yin,Carl S Thummel,Arash Bashirullah,

A pulse of the steroid hormone ecdysone triggers the destruction of larval salivary glands during Drosophila metamorphosis through a transcriptional cascade that converges on reaper (rpr) and head involution defective (hid) induction, resulting in caspase activation and cell death. We identify the CREB binding protein (CBP) transcriptional cofactor as essential for salivary gland cell death. We show that CBP acts 1 d before the onset of metamorphosis in apparent response to a mid-third instar ecdysone pulse, when CBP is necessary and sufficient for down-regulation of the Drosophila inhibitor of apoptosis 1 (DIAP1). It is only after DIAP1 levels are reduced that salivary glands become competent to die through rpr/hid-mediated cell death. Before this time, high levels of DIAP1 block salivary gland cell death, even in the presence of ectopic rpr expression. This study shows that naturally occurring changes in inhibitor of apoptosis levels can be critical for regulating cell death during development. It also provides a molecular mechanism for the acquisition of competence in steroid signaling pathways.

Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. Publishing Authors By Initials

VP Yin,CS Thummel,A Bashirullah,VP Yin,CS Thummel,A Bashirullah,

For similar polycyclic compounds: steroids research abstracts see: polycyclic compounds: steroids research

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Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of cell biology

VOLUME: 178

Page Numbers: 85-92

Journal Abbreviation: J. Cell Biol.

ISSN: 0021-9525

DAY: 25

MONTH: 06

YEAR: 2007

Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. Information

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LANGUAGE: eng

NlmUniqueID: 375356

Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. Keywords Mesh Terms:

KEYWORDS: Steroids

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. Information

Substance Name: Steroids

Registry Number: 0

Grant and Affiliation Information for Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death.

AFFILIATION: Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM073670

ACRONYM: GM

MEDLINETA: J Cell Biol

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