Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells.

Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Research Abstract Details 

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Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Abstract Text:

Guofeng Cheng,Jin Zhong,Josan Chung,Francis V Chisari,

Virus infection triggers IFN immune defenses in infected cells in part through viral nucleic acid interactions, but the pathways by which dsDNA and DNA viruses trigger innate defenses are only partially understood. Here we present evidence that both retinoic acid-induced gene I (RIG-I) and mitochondrial antiviral signaling protein (MAVS) are required for dsDNA-induced IFN-beta promoter activation in a human hepatoma cell line (Huh-7), and that activation is efficiently blocked by the hepatitis C virus NS3/4A protease, which is known to block dsRNA signaling by cleaving MAVS. These findings suggest that dsDNA and dsRNA share a common pathway to trigger the innate antiviral defense response in human cells, although dsDNA appears to trigger that pathway upstream of the dsRNA-interacting protein RIG-I.

Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Publishing Authors By Initials

G Cheng,J Zhong,J Chung,FV Chisari,

For similar proteins: viral proteins: viral nonstructural proteins research abstracts see: proteins: viral proteins: viral nonstructural proteins research

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Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 9035-40

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 15

MONTH: 05

YEAR: 2007

Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Keywords Mesh Terms:

KEYWORDS: Viral Nonstructural Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Information

Substance Name: DDX58 protein, human

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells.

AFFILIATION: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01-CA108304

ACRONYM: CA

MEDLINETA: Proc Natl Acad Sci U S A

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