Double-inducible gene activation system for caspase 3 and 9 in epidermis.

Double-inducible gene activation system for caspase 3 and 9 in epidermis. Research Abstract Details 

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Double-inducible gene activation system for caspase 3 and 9 in epidermis. Abstract Text:

Viraj R Shah,Maranke I Koster,Dennis R Roop,David M Spencer,Lei Wei,Qi Li,Robert J Schwartz,Jiang Chang,

Expression of genes with tight and precise temporal and spatial control is desired in a wide variety of applications ranging from cultured cells and transgenic animals to gene therapy. While current inducible systems, such as RU486 and chemical inducers of dimerization (CID), have improved earlier inducible models (Gossen et al., 1995, Science. 268:1766-1769; Wang et al., 1994, Proc Natl Acad Sci USA 91:8180-8184), no single system is perfect at present. One potential drawback of these systems is leakage of transgene expression, causing limitations of each system. We have developed an inducible model containing both RU486 and CID systems, which in addition to inducing caspase activation, has potential applicability specifically to other genes encoding proteins that require a dimerization event for activation. This Double-Inducible Gene Activation System generates two barriers for the target gene expression and protein activation thereby minimizing leakage.

Double-inducible gene activation system for caspase 3 and 9 in epidermis. Publishing Authors By Initials

VR Shah,MI Koster,DR Roop,DM Spencer,L Wei,Q Li,RJ Schwartz,J Chang,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: protein binding research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: protein binding research

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Double-inducible gene activation system for caspase 3 and 9 in epidermis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genesis (New York, N.Y. : 2000)

VOLUME: 45

Page Numbers: 194-9

Journal Abbreviation:

ISSN: 1526-954X

DAY: 3

MONTH: Apr

YEAR: 2007

Double-inducible gene activation system for caspase 3 and 9 in epidermis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100931242

Double-inducible gene activation system for caspase 3 and 9 in epidermis. Keywords Mesh Terms:

KEYWORDS: Protein Binding

MESH TERMS: drug effects

Chemical & Substance for Abstract: Double-inducible gene activation system for caspase 3 and 9 in epidermis. Information

Substance Name: Caspase 9

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Double-inducible gene activation system for caspase 3 and 9 in epidermis.

AFFILIATION: Center for Molecular Development and Disease, Texas A and M University Health Science Center, Institute of Biosciences and Technology, Houston, Texas 77030, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01-HL72897

ACRONYM: HL

MEDLINETA: Genesis

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