Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma.

Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma. Abstract Text:

C P Chiu,J L Huang,T Y Lin,W B Shieh,K H Hsieh,

Oxatomide is an orally active H1-histamine receptor antagonist. It has been demonstrated to have therapeutic efficacy in the treatment of allergic diseases in adults. The aim of this study was to evaluate the efficacy and safety of oxatomide in the treatment of asthma in children. Sixty-four asthmatic children of both sexes, aged between 5 and 16 years, were enrolled in this double-blind, placebo-controlled trial with a duration of 4 months. Patients were randomized chosen to receive either oxatomide with a daily dose of 1 to 2 mg/kg body weight or a placebo twice daily. Clinical evaluations including pulmonary function tests and immunological studies. The patients' impression on the effect of treatment also were recorded during the study. The effects of bronchodilatation and normalizing pulmonary function were observed 2 months after oxatomide treatment. The levels of eosinophil cationic protein and total asthma symptom scores were significantly reduced during treatment with oxatomide. There was no significant change in total IgE or IgG4 before or after treatment in either the treatment or control groups. During the study, two (5.8%) oxatomide treated patients reported slight drowsiness and one (2.9%) reported body weight gain. Routine laboratory tests showed no significant alterations. In conclusion, oxatomide was generally well tolerated in this study and may have the potential of being an effective treatment for childhood asthma.

Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma. Publishing Authors By Initials

CP Chiu,JL Huang,TY Lin,WB Shieh,KH Hsieh,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: piperazines research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: piperazines research

PUBMED ID PMID:

MEDLINE DATE:

Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua Minguo xiao er ke yi xue hui za zhi [Jour

VOLUME: 38

Page Numbers: 14-20

Journal Abbreviation:

ISSN: 0001-6578

DAY: 12

MONTH: 02

YEAR: 2008

Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 16210470

Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma. Keywords Mesh Terms:

KEYWORDS: Piperazines

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma. Information

Substance Name: oxatomide

Registry Number: 60607-34-3

Grant and Affiliation Information for Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma.

AFFILIATION: Department of Pediatrics, Chang Gung Children's Hospital, Linko, Taiwan, R.O.C.

Country: TAIWAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Min Guo Xiao Er Ke Yi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma Related Publications

• A noninvasive sizing method to choose fitted Amplatzer septal occluder by transthoracic echocardiography in patients with secundum atrial septal defects.
• A prospective study of the transient decrease in ovarian cancer risk following childbirth.
• ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts.
• Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.
• Combination of transverse myelitis and arachnoiditis in cauda equina syndrome of long-standing ankylosing spondylitis: MRI features and its role in clinical management.
• Component and intrinsic motion integrate in 'dancing bar' illusion.
• Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis.
• DNA methylation dictates histone H3K4 methylation.
• Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder.
• Degradation of phenol and TCE using suspended and chitosan-bead immobilized Pseudomonas putida.
• Development and validation of a WHOQOL-BREF Taiwanese audio player-assisted interview version for the elderly who use a spoken dialect.
• Effects of music on gastric myoelectrical activity in healthy humans.
• Elevated plasma factor VIII coagulant activity presenting with thrombophlebitis of the deep dorsal vein of the penis.
• Feasibility and safety of transradial stenting for unprotected left main coronary artery stenoses.
• Fifteen-year experience of children with Henoch-Schönlein purpura in southern Taiwan, 1991-2005.
• Healthcare payment incentives : a comparative analysis of reforms in taiwan, South Korea and china.
• Identification of regional air pollution characteristic and the correlation with public health in Taiwan.
• Lack of prognostic value of EGFR mutations in primary resected non-small cell lung cancer.
• Levels and correlates of alpha-fetoprotein in normal pregnancies among Caucasian and Chinese women.
• Mechanism of increased coxsackie and adenovirus receptor gene expression and adenovirus uptake by phytoestrogen and histone deacetylase inhibitor in human bladder cancer cells and the potential clinical application.
• Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro.
• Optimal design of resonant piezoelectric buzzer from a perspective of vibration-absorber theory.
• P42.06: Uterine arteriovenous malformations with three-dimensional presentation: a case report.
• Personality and physical activity: 1971: board #41 may 31 2:00 PM - 3:30 PM.
• Single wire versus double wire loops for median sternotomy closure: experimental biomechanical study using a human cadaveric model.
• Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase II.
• Surface plasmon resonance biosensor based on electro-optically modulated phase detection.
• The assistance of microwave process in sludge stabilization with sodium sulfide and sodium phosphate.
• The infinite regress illusion reveals faulty integration of local and global motion signals.
• Three-dimensional cryotransmission electron microscopy of cells and organelles.