Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults.

Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults. Research Abstract Details 

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Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults. Abstract Text:

Carol J Baker,Marcia A Rench,Lawrence C Paoletti,Morven S Edwards,

A phase 1, dose-escalating trial was conducted in healthy adults to evaluate immunogenicity and reactogenicity of a type V group B streptococcal (GBS) capsular polysaccharide (CPS)-tetanus toxoid (TT) conjugate vaccine. Participants received one dose of unconjugated V CPS (37 microg), V-TT (2.4 microg CPS/1.1 microg TT), V-TT (9.6 microg CPS/4.3 microg TT) or V-TT (38.5 microg CPS/17.0 microg TT). Each vaccine and all doses of V-TT were well-tolerated. V CPS-specific antibodies reached a peak 4-8 weeks after immunization and were significantly higher through 52 weeks post-immunization in recipients of V-TT at each dose than in uncoupled CPS vaccinees. V-TT vaccine-induced antibodies promoted opsonophagocytic killing of type V GBS and avidity maturation of V CPS-specific IgG.

Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults. Publishing Authors By Initials

CJ Baker,MA Rench,LC Paoletti,MS Edwards,

For similar vaccines, conjugate research abstracts see: vaccines, conjugate research

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MEDLINE DATE:

Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Vaccine

VOLUME: 25

Page Numbers: 55-63

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 31

MONTH: 07

YEAR: 2006

Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8406899

Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults. Keywords Mesh Terms:

KEYWORDS: Vaccines, Conjugate

MESH TERMS: immunology

Chemical & Substance for Abstract: Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults. Information

Substance Name: streptococcal polysaccharide-tetanus tox

Registry Number: 0

Grant and Affiliation Information for Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults.

AFFILIATION: Section of Infectious Diseases, Department of Pediatrics, Room 302A, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States. cbaker@bcm.tmc.edu

Country: Netherlands

AGENCY: United States NIAID

GRANT: N01 AI-75326

ACRONYM: AI

MEDLINETA: Vaccine

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