Dose effects of triazolam on brain activity during episodic memory encoding: a PET study.

Dose effects of triazolam on brain activity during episodic memory encoding: a PET study. Research Abstract Details 

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Dose effects of triazolam on brain activity during episodic memory encoding: a PET study. Abstract Text:

Miriam Z Mintzer,Hiroto Kuwabara,Mohab Alexander,James R Brasic,Weiguo Ye,Monique Ernst,Roland R Griffiths,Dean F Wong,

RATIONALE: Although it is well established that acute benzodiazepine administration impairs episodic memory encoding, little is known about the neuroanatomical substrates of this effect. OBJECTIVE: The objective was to examine the acute dose effects of the benzodiazepine hypnotic triazolam on brain activity during episodic memory encoding. METHODS: After oral capsule administration (placebo, 0.1, 0.2, and 0.4 mg/70 kg triazolam), regional cerebral blood flow (rCBF) was measured using positron emission tomography (PET) with 15O-H2O during performance of semantic categorization and orthographic categorization tasks in a double-blind, within-subject design in 12 healthy volunteers. The rCBF associated with episodic memory encoding was measured by subtracting the rCBF during orthographic categorization from that during semantic categorization and by examining correlations between brain activity during encoding and subsequent recognition memory performance. RESULTS: Results in the placebo condition replicated those of nonpharmacological encoding studies, including activation in left ventrolateral prefrontal cortex. Correlations between brain activity and subsequent memory performance additionally showed medial temporal activation. Triazolam produced dose-related impairment in memory performance and dose-related deactivation in encoding-associated areas including right prefrontal cortex, left parahippocampal gyrus, and left anterior cingulate cortex. CONCLUSIONS: Results are consistent with behavioral evidence that benzodiazepines impair prefrontal control processes as well as contextual memory and episodic binding processes thought to be controlled by the medial temporal lobe. In addition to elucidating the brain mechanisms underlying these benzodiazepine-induced behavioral deficits, results of this study also help validate hypotheses generated in nonpharmacological neuroimaging studies regarding the processes controlled by these brain regions.

Dose effects of triazolam on brain activity during episodic memory encoding: a PET study. Publishing Authors By Initials

MZ Mintzer,H Kuwabara,M Alexander,JR Brasic,W Ye,M Ernst,RR Griffiths,DF Wong,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzazepines: benzodiazepines: triazolam research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzazepines: benzodiazepines: triazolam research

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Dose effects of triazolam on brain activity during episodic memory encoding: a PET study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychopharmacology

VOLUME: 188

Page Numbers: 445-61

Journal Abbreviation: Psychopharmacology (Berl.)

ISSN: 0033-3158

DAY: 18

MONTH: 07

YEAR: 2006

Dose effects of triazolam on brain activity during episodic memory encoding: a PET study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7608025

Dose effects of triazolam on brain activity during episodic memory encoding: a PET study. Keywords Mesh Terms:

KEYWORDS: Triazolam

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Dose effects of triazolam on brain activity during episodic memory encoding: a PET study. Information

Substance Name: Triazolam

Registry Number: 28911-01-5

Grant and Affiliation Information for Dose effects of triazolam on brain activity during episodic memory encoding: a PET study.

AFFILIATION: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. mmintzer@jhmi.edu

Country: Germany

AGENCY: United States NIDA

GRANT: R01 DA-14101

ACRONYM: DA

MEDLINETA: Psychopharmacology (Berl)

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