Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways.

Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Research Abstract Details 

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Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Abstract Text:

Tao Lu,Liping Tian,Yulong Han,Michael Vogelbaum,George R Stark,

Some tumor cell lines secrete high concentrations of TGFbeta or IL-1. Similarly high concentrations of each of these cytokines cross-activate the other pathway: TGFbeta activates NFkappaB, and IL-1beta activates Smads. The IL-1 signaling components IRAK, MyD88, TRAF6, and TAK1 are all required for cross-activation of NFkappaB by TGFbeta. Knockdown experiments revealed that both TGFbeta receptor subunits are required for IL-1beta to activate Smads, and the IL-1 receptor is required for TGFbeta to activate NFkappaB. Coimmunoprecipitations showed that either TGFbeta or IL-1beta stimulate ligand-dependent association of all three receptor subunits. Furthermore, cross-talk between the TGFbeta and IL-1 signaling pathways leads to dose-dependent cross-control of gene expression. These interactions provide new insight into biological responses to IL-1 and TGFbeta in the proximity of tumors that secrete high concentrations of these factors and probably also at sites of inflammation, where the local concentrations of these cytokines are likely to be high.

Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Publishing Authors By Initials

T Lu,L Tian,Y Han,M Vogelbaum,GR Stark,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 4365-70

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 5

MONTH: 03

YEAR: 2007

Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Information

Substance Name: MAP Kinase Kinase Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways.

AFFILIATION: Department of Molecular Genetics, Lerner Research Institute, and Brain Tumor Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Country: United States

AGENCY: United States NCI

GRANT: P01 CA 62220

ACRONYM: CA

MEDLINETA: Proc Natl Acad Sci U S A

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