In the dorsal horn of the chick embryo spinal cord, extracellular signal-regulated kinase (ERK) was phosphorylated transiently during embryonic days 6 and 9. Co-culture studies suggested that dorsal root ganglion (DRG) activated ERK in the dorsal horn. Brain-derived neurotrophic factor (BDNF) activated ERK in the dorsal horn, and anti-BDNF blocked the DRG-induced ERK activation. These results suggest roles of BDNF in the DRG-induced ERK activation in the embryonic dorsal horn.
Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development. Publishing Authors By Initials
Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development. Journal Published:
PUBLICATION TYPE: Research Support, Non-U.S. Gov
Journal: Neuroscience research
VOLUME: 58
Page Numbers: 402-5
Journal Abbreviation: Neurosci. Res.
ISSN: 0168-0102
DAY: 29
MONTH: 04
YEAR: 2007
Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development. Information
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LANGUAGE: eng
NlmUniqueID: 8500749
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Grant and Affiliation Information for Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development.
AFFILIATION: Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.
Country: Ireland
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MEDLINETA: Neurosci Res
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