Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone.

Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone. Research Abstract Details 

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Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone. Abstract Text:

Mark Niedringhaus,Patrick G Jackson,Stephen R T Evans,Joseph G Verbalis,Richard A Gillis,Niaz Sahibzada,Mark Niedringhaus,Patrick G Jackson,Stephen R T Evans,Joseph G Verbalis,Richard A Gillis,Niaz Sahibzada,

The sphincter mechanism at the esophagogastric junction includes smooth muscle of the lower esophagus and skeletal muscle of the crural diaphragm (CD). Smooth muscle is known to be under the control of the dorsal motor nucleus of the vagus (DMV), while central nervous system (CNS) control of the CD is unknown. The main purposes of our study were to determine the CNS site that controls the CD and whether simultaneous changes in lower esophageal sphincter (LES) pressure and CD activity occur when this site is activated. Experiments were performed on anesthetized male ferrets whose LES pressure, CD activity, and fundus tone were monitored. To activate DMV neurons, l-glutamate was microinjected unilaterally into the DMV at three areas: intermediate, rostral, and caudal. Stimulation of the intermediate DMV decreased CD activity (-4.8 +/- 0.1 bursts/min and -0.3 +/- 0.01 mV) and LES pressure (-13.2 +/- 2.0 mmHg; n = 9). Stimulation of this brain site also produced an increase in fundus tone. Stimulation of the rostral DMV elicited increases in the activity of all three target organs (n = 5). Stimulation of the caudal DMV had no effect on the CD but did decrease both LES pressure and fundus tone (n = 5). All changes in LES pressure, fundus tone, and some DMV-induced changes in CD activity (i.e., bursts/min) were prevented by ipsilateral vagotomy. Our data indicate that simultaneous changes in activity of esophagogastric sphincters and fundus tone occur from rostral and intermediate areas of the DMV and that these changes are largely mediated by efferent vagus nerves.

Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone. Publishing Authors By Initials

M Niedringhaus,PG Jackson,SR Evans,JG Verbalis,RA Gillis,N Sahibzada,M Niedringhaus,PG Jackson,SR Evans,JG Verbalis,RA Gillis,N Sahibzada,

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Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of physiology. Regulatory, integr

VOLUME: 294

Page Numbers: R121-31

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 31

MONTH: 10

YEAR: 2007

Dorsal motor nucleus of the vagus: a site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure, and fundus tone. Information

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LANGUAGE: eng

NlmUniqueID: 100901230

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AFFILIATION: Dept. of Pharmacology, Georgetown Univ. Medical Center, 3900 Reservoir Rd., NW, Washington, DC 20007. sahibzan@georgetown.edu).

Country: United States

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MEDLINETA: Am J Physiol Regul Integr Comp

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