Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype.

Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype. Research Abstract Details 

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Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype. Abstract Text:

Elizabeth ,Carlos Cepeda,Marjorie A Ariano,Mary Kay Lobo,David R Sibley,Michael S Levine,

Dopamine modulates voltage- and ligand-gated currents in striatal medium-sized neurons (MSNs) through the activation of D1- and D2-like family receptors. GABA(A) receptor-mediated currents are reduced by D1 receptor agonists, but the relative contribution of D(1) or D(5 )receptors in this attenuation has been elusive due to the lack of selective pharmacological agents. Here we examined GABA(A) receptor-mediated currents and the effects of D1 agonists on MSNs from wildtype and D(1) or D(5 )receptor knockout (KO) mice. Immunohistochemical and single-cell RT-PCR studies demonstrated a lack of compensatory effects after genetic deletion of D(1) or D(5) receptors. However, the expression of GABA(A )receptor alpha1 subunits was reduced in D(5) KO mice. At the functional level, whole-cell patch clamp recordings in dissociated MSNs showed that GABA peak current amplitudes were smaller in cells from D(5) KO mice indicating that lack of this receptor subtype directly affected GABA(A)-mediated currents. In striatal slices, addition of a D1 agonist reduced GABA currents significantly more in D(5) KO compared to D(1) KO mice. We conclude that D(1) receptors are the main D1-like receptor subtype involved in the modulation of GABA currents and that D(5) receptors contribute to the normal expression of these currents in the striatum.

Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype. Publishing Authors By Initials

E ,C Cepeda,MA Ariano,MK Lobo,DR Sibley,MS Levine,

For similar organic chemicals: amides: benzamides: sulpiride research abstracts see: organic chemicals: amides: benzamides: sulpiride research

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Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurochemical research

VOLUME: 32

Page Numbers: 229-40

Journal Abbreviation: Neurochem. Res.

ISSN: 0364-3190

DAY: 22

MONTH: 09

YEAR: 2006

Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype. Information

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LANGUAGE: eng

NlmUniqueID: 7613461

Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype. Keywords Mesh Terms:

KEYWORDS: Sulpiride

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype. Information

Substance Name: SK&F 83566

Registry Number: 94344-79-3

Grant and Affiliation Information for Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype.

AFFILIATION: Mental Retardation Research Center, Room 58-258 David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS33538

ACRONYM: NS

MEDLINETA: Neurochem Res

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