Dopamine receptor upregulation in Lesch-Nyhan syndrome: a postmortem study.

Dopamine receptor upregulation in Lesch-Nyhan syndrome: a postmortem study. Research Abstract Details 

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Dopamine receptor upregulation in Lesch-Nyhan syndrome: a postmortem study. Abstract Text:

Y Saito,M Ito,S Hanaoka,E Ohama,S Akaboshi,S Takashima,Y Saito,M Ito,S Hanaoka,E Ohama,S Akaboshi,S Takashima,

The brains of two patients with Lesch-Nyhan syndrome (LNS) were studied. The concentration of dopamine was decreased in the caudate nucleus of LNS patients. Immunohistochemical methods revealed that the dopamine (DA) D1 and D2 receptor and methionine-enkephalin immunoreactivities (IRs) were increased in the putamen, and less significantly in the caudate nucleus. The D1 and D2 receptor IRs of the cingulate cortex, the tryptophan-hydroxylase IR in the dorsal nucleus of the midbrain, as well as the substance P and methionine-enkephalin IRs of the nociception-conducting structures, including the periaqueductal gray and spinal trigeminal nucleus, were not changed. Tyrosine-hydroxylase IR was not decreased in the substantia nigra of the LNS patients. Therefore, the cause of the decreased dopaminergic activity in LNS may not be involved in the production of tyrosine hydroxylase in the substantia nigra. Developmental abnormalities due to the DA defect at an early age might exist in the postsynaptic structure in the striatum.

Dopamine receptor upregulation in Lesch-Nyhan syndrome: a postmortem study. Publishing Authors By Initials

Y Saito,M Ito,S Hanaoka,E Ohama,S Akaboshi,S Takashima,Y Saito,M Ito,S Hanaoka,E Ohama,S Akaboshi,S Takashima,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Dopamine receptor upregulation in Lesch-Nyhan syndrome: a postmortem study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuropediatrics

VOLUME: 30

Page Numbers: 66-71

Journal Abbreviation: Neuropediatrics

ISSN: 0174-304X

DAY: 16

MONTH: Apr

YEAR: 1999

Dopamine receptor upregulation in Lesch-Nyhan syndrome: a postmortem study. Information

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LANGUAGE: eng

NlmUniqueID: 8101187

Dopamine receptor upregulation in Lesch-Nyhan syndrome: a postmortem study. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Dopamine receptor upregulation in Lesch-Nyhan syndrome: a postmortem study. Information

Substance Name: Tyrosine 3-Monooxygenase

Registry Number: EC 1.14.16.2

Grant and Affiliation Information for Dopamine receptor upregulation in Lesch-Nyhan syndrome: a postmortem study.

AFFILIATION: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.

Country: GERMANY

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MEDLINETA: Neuropediatrics

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