Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals.

Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals. Research Abstract Details 

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Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals. Abstract Text:

D S Melchitzky,S L Erickson,D A Lewis,

Dopamine (DA) axons and receptors have recently been identified in the primate thalamus, including the mediodorsal thalamic nucleus (MD). In order to determine whether the DA innervation of the primate MD shares the anatomical features of the mesocortical or nigrostriatal DA projections, we performed tract-tracing and immunocytochemistry studies in macaque monkeys (Macaca fascicularis) to identify the location of the DA neurons that project to MD and immuno-electron microscopy to determine the distribution of the dopamine transporter (DAT) in axons within the MD. Similar to the mesocortical projection, retrogradely-labeled, tyrosine hydroxylase-containing neurons were present in dorsal tier ventral mesencephalic nuclei, such as the ventral tegmental area and the dorsal portion of the substantia nigra pars compacta. In contrast, no dual-labeled neurons were present in the ventral tier nuclei, the primary origin of the nigrostriatal DA pathway. In addition, like the DA projection to the prefrontal cortex, DAT immunoreactivity was predominantly localized to the pre-terminal portion of axons in the MD, and was infrequently found in association with synaptic vesicles, in contrast to nigrostriatal DA axons. These findings indicate that the DA projection to the MD shares anatomical features with the mesocortical DA system, suggesting that the functional properties of DA neurotransmission in the MD might be more similar to those in the cortex than in the striatum.

Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals. Publishing Authors By Initials

DS Melchitzky,SL Erickson,DA Lewis,

For similar nervous system: central nervous system: brain: brain stem: mesencephalon: tegmentum mesencephali: ventral tegmental area research abstracts see: nervous system: central nervous system: brain: brain stem: mesencephalon: tegmentum mesencephali: ventral tegmental area research

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Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroscience

VOLUME: 143

Page Numbers: 1021-30

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 9

MONTH: 10

YEAR: 2006

Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7605074

Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals. Keywords Mesh Terms:

KEYWORDS: Ventral Tegmental Area

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals. Information

Substance Name: Tyrosine 3-Monooxygenase

Registry Number: EC 1.14.16.2

Grant and Affiliation Information for Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals.

AFFILIATION: Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH 051234

ACRONYM: MH

MEDLINETA: Neuroscience

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