Dopamine inhibits the aldosterone response to upright posture.

Dopamine inhibits the aldosterone response to upright posture. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Dopamine inhibits the aldosterone response to upright posture. Abstract Text:

C D Malchoff,J Hughes,S Sen,S Jackson,R M Carey,

Aldosterone secretion in man is stimulated by potassium, ACTH, and angiotensin II and is inhibited by dopamine (DA). In normal sodium-replete supine individuals, aldosterone secretion is under maximum tonic inhibition by DA. Dopaminergic control of aldosterone secretion is modified by dietary sodium depletion. To determine the physiological significance of dopaminergic inhibition of aldosterone secretion, we studied the effect of DA on the aldosterone response to upright posture. Twelve normal men were studied while eating an ad libitum sodium diet, and the effect of DA was determined in the supine and upright positions. Plasma aldosterone (PAC), plasma cortisol (F), plasma aldosterone-stimulating factor (ASF), PRA, and blood pressure were measured while the men were supine and after 4 h of upright posture during an infusion of 5% dextrose vehicle and during a DA infusion of 4.0 micrograms/kg X min. The men also were studied as a time control in the supine position while receiving vehicle or DA. PAC increased from a mean basal value of 20.4 +/- 3.2 ng/dl (+/- SE) by 25.9 +/- 5.1 ng/dl to a peak of 44.4 +/- 2.4 ng/dl in response to upright posture during vehicle infusion. The PAC response to upright posture was reduced to 7.4 +/- 1.8 ng/dl (P less than 0.05) when DA was infused. The increase in PRA with upright posture was 3.7 +/- 1.3 ng/ml X h during the vehicle infusion and 4.1 +/- 1.1 ng/ml X h (P = NS) during the DA infusion. ASF, F, and blood pressure were not altered by upright posture and DA. PAC did not change in the six men infused with DA while supine. Therefore, DA inhibits upright aldosterone responses without affecting PRA, ASF, or F.

Dopamine inhibits the aldosterone response to upright posture. Publishing Authors By Initials

CD Malchoff,J Hughes,S Sen,S Jackson,RM Carey,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: aspartic endopeptidases: renin research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: aspartic endopeptidases: renin research

PUBMED ID PMID:

MEDLINE DATE:

Dopamine inhibits the aldosterone response to upright posture. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 63

Page Numbers: 197-201

Journal Abbreviation: J. Clin. Endocrinol. Metab.

ISSN: 0021-972X

DAY: 19

MONTH: Jul

YEAR: 1986

Dopamine inhibits the aldosterone response to upright posture. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375362

Dopamine inhibits the aldosterone response to upright posture. Keywords Mesh Terms:

KEYWORDS: Renin

MESH TERMS: blood

Chemical & Substance for Abstract: Dopamine inhibits the aldosterone response to upright posture. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Dopamine inhibits the aldosterone response to upright posture.

AFFILIATION:

Country: UNITED STATES

AGENCY: United States NCRR

GRANT: RR-847

ACRONYM: RR

MEDLINETA: J Clin Endocrinol Metab

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Dopamine inhibits the aldosterone response to upright posture Related Publications

• Aldosterone-stimulating factor is increased in idiopathic hyperaldosteronism.
• An affective and cognitive model of marijuana and alcohol problems.
• Association between alcohol intoxication and alcohol-related problems: an event-level analysis.
• Behavioral HIV risk reduction among people who inject drugs: meta-analytic evidence of efficacy.
• Bioconductor: an open source framework for bioinformatics and computational biology.
• Development and psychometric evaluation of a self-administered questionnaire to measure knowledge of sexually transmitted diseases.
• Distinct biological epochs in the reproductive life of female Drosophila melanogaster.
• Dopamine inhibits the aldosterone response to upright posture.
• Efficient inhibition of class A and class D beta-lactamases by Michaelis complexes.
• Extraordinary long life spans in fruit-feeding butterflies can provide window on evolution of life span and aging.
• Functional cooperation between HP1 and DNMT1 mediates gene silencing.
• Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells: activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase inhibitors.
• How the quality of peer relationships influences college alcohol use.
• Imaging mitogen-activated protein kinase function in xenograft models of prostate cancer.
• Intimate partner violence and sexual coercion among pregnant women in India: relationship with depression and post-traumatic stress disorder.
• Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats.
• Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism.
• Knowing who dunnit: Infants identify the causal agent in an unseen causal interaction.
• Neural changes in control implementation of a continuous task.
• On the relation between the acquisition of singular-plural morpho-syntax and the conceptual distinction between one and more than one.
• One, two, three, four, nothing more: an investigation of the conceptual sources of the verbal counting principles.
• Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
• Response and cardiac toxicity of trastuzumab given in conjunction with weekly paclitaxel after doxorubicin/cyclophosphamide.
• Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking.
• Spectroscopic characterization of distortion in enzyme complexes.
• Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures.
• The use of anterolateral bowing of the lower leg in the diagnostic criteria for neurofibromatosis type 1.
• Tissue-preserving approach to extracting DNA from paraffin-embedded specimens using tissue microarray technology.
• Two unique patients with novel microdeletions in 4p16.3 that exclude the WHS critical regions: implications for critical region designation.
• [Vestibulo-oculomotor reflex recording using the scleral search coil technique. Review of peripheral vestibular disorders]