Dopamine induces a slow afterdepolarization in lateral amygdala neurons.

Dopamine induces a slow afterdepolarization in lateral amygdala neurons. Research Abstract Details 

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Dopamine induces a slow afterdepolarization in lateral amygdala neurons. Abstract Text:

Ryo Yamamoto,Yoshifumi Ueta,Nobuo Kato,Ryo Yamamoto,Yoshifumi Ueta,Nobuo Kato,

The amygdala and dopaminergic innervation thereunto are considered to cooperatively regulate emotional states and behaviors. The present experiments examined effects of dopamine on lateral amygdala (LA) neuron excitability by whole cell recordings. Bath application of dopamine induced slow afterdepolarization (sADP). This sADP lasted for >5 s, and its magnitude varied in a concentration-dependent manner. Co-application of the D1 receptor antagonist SKF83566 reduced its amplitude. The D1 receptor agonist SKF38393, applied alone, induced sADP of a smaller amplitude. Induction of the full sADP required 5-HT(2) and noradrenalin alpha(1) receptor activation as well. D2 receptor activation or blockade did not affect sADP induction. The calcium channel blocker cadmium or intracellular calcium chelator bis-(o-aminophenoxy)-N,N,N',N' tetraacetic acid (BAPTA) blocked induction of the sADP, which was suggested to be triggered by calcium influx. Under voltage clamp, membrane conductance decreased at the peak of sADP current (I(sADP)). I(sADP) was suppressed by cesium included in pipettes. The I-V curve of the net I(sADP) was shifted as the external concentration of potassium was raised, and the reversal potential was identical to that of potassium, suggesting that dopamine decreases potassium conductance to induce the sADP. The present sADP may serve as a positive-feedback regulator of excitability in LA neurons.

Dopamine induces a slow afterdepolarization in lateral amygdala neurons. Publishing Authors By Initials

R Yamamoto,Y Ueta,N Kato,R Yamamoto,Y Ueta,N Kato,

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Dopamine induces a slow afterdepolarization in lateral amygdala neurons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neurophysiology

VOLUME: 98

Page Numbers: 984-92

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 6

MONTH: 06

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Dopamine induces a slow afterdepolarization in lateral amygdala neurons.

AFFILIATION: Department of Physiology, Kanazawa Medical University, Ishikawa, Japan.

Country: United States

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MEDLINETA: J Neurophysiol

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