Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitro.

Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitro. Research Abstract Details 

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Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitro. Abstract Text:

Javorina Milosevic,Sigrid C Schwarz,Martina Maisel,Monika Poppe-Wagner,Maja-Theresa Dieterlen,Alexander Storch,Johannes Schwarz,Javorina Milosevic,Sigrid C Schwarz,Martina Maisel,Monika Poppe-Wagner,Maja-Theresa Dieterlen,Alexander Storch,Johannes Schwarz,

The potential application of neural precursor cells (NPCs) in brain repair of neurodegenerative diseases has placed the factors capable of stimulating neurogenesis under increasing attention. Among these factors are dopamine (DA) D2/D3 receptor agonists, like 7-hydroxy-dipropylaminotetralin (7-OH-DPAT). The purpose of this investigation was to explore proliferating and neurostimulating effects of this drug in murine and human NPCs derived from the fetal midbrain. In both cell types, dopamine D2 and D3 receptors were detected by microarray data analysis and quantitative RT-PCR. Despite D2/D3 receptors expression, treatment with 7-OH-DPAT did not affect proliferation, survival, or neurogenesis of murine and human NPCs. Our data question the relevance of neuroregenerative effects of dopamine agonists for human predopaminergic cells as well as patients with Parkinson's disease.

Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitro. Publishing Authors By Initials

J Milosevic,SC Schwarz,M Maisel,M Poppe-Wagner,MT Dieterlen,A Storch,J Schwarz,J Milosevic,SC Schwarz,M Maisel,M Poppe-Wagner,MT Dieterlen,A Storch,J Schwarz,

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Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitro. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Stem cells and development

VOLUME: 16

Page Numbers: 625-35

Journal Abbreviation: Stem Cells Dev.

ISSN: 1547-3287

DAY: 5

MONTH: Aug

YEAR: 2007

Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitro. Information

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LANGUAGE: eng

NlmUniqueID: 101197107

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Grant and Affiliation Information for Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitro.

AFFILIATION: Translational Centre for Regenerative Medicine, Leipzig, 04103 Leipzig, Germany., Department of Neurology, University of Leipzig, 04103, Germany. jmilosevic@trm.uni-leipzig.de

Country: United States

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MEDLINETA: Stem Cells Dev

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