We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.
Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. Publishing Authors By Initials
Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. Journal Published:
PUBLICATION TYPE: Research Support, Non-U.S. Gov
Journal: Journal of the American Chemical Society
VOLUME: 126
Page Numbers: 9938-9
Journal Abbreviation: J. Am. Chem. Soc.
ISSN: 0002-7863
DAY: 18
MONTH: Aug
YEAR: 2004
Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. Information
Number of References:
LANGUAGE: eng
NlmUniqueID: 7503056
Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. Keywords Mesh Terms:
KEYWORDS: Spectrophotometry, Ultraviolet
MESH TERMS: isolation & purification
Chemical & Substance for Abstract: Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles. Information
Substance Name: Histidine
Registry Number: 71-00-1
Grant and Affiliation Information for Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles.
AFFILIATION: Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Country: United States
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MEDLINETA: J Am Chem Soc
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