Domains in the XPA protein important in its role as a processivity factor.

Domains in the XPA protein important in its role as a processivity factor. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Domains in the XPA protein important in its role as a processivity factor. Abstract Text:

Claudine L Bartels,Muriel W Lambert,

XPA is a protein essential for nucleotide excision repair (NER) where it is thought to function in damage recognition/verification. We have proposed an additional role, that of a processivity factor, conferring a processive mechanism of action on XPF and XPG, the endonucleases, involved in NER. The present study was undertaken to examine the domain(s) in the XPA gene that are important for the ability of the XPA protein to function as a processivity factor. Using site-directed mutagenesis, mutations were created in several of the exons of XPA and mutant XPA proteins produced. The results showed that the DNA binding domain of XPA is critical for its ability to act as a processivity factor. Mutations in both the zinc finger motif and the large basic cleft in this domain eliminated the ability of XPA to confer a processive mechanism of action on the endonucleases involved in NER.

Domains in the XPA protein important in its role as a processivity factor. Publishing Authors By Initials

CL Bartels,MW Lambert,

For similar proteins: dna-binding proteins: xeroderma pigmentosum group a protein research abstracts see: proteins: dna-binding proteins: xeroderma pigmentosum group a protein research

PUBMED ID PMID:

MEDLINE DATE:

Domains in the XPA protein important in its role as a processivity factor. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochemical and biophysical research communication

VOLUME: 356

Page Numbers: 219-25

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 2

MONTH: 03

YEAR: 2007

Domains in the XPA protein important in its role as a processivity factor. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Domains in the XPA protein important in its role as a processivity factor. Keywords Mesh Terms:

KEYWORDS: Xeroderma Pigmentosum Group A Protein

MESH TERMS: physiology

Chemical & Substance for Abstract: Domains in the XPA protein important in its role as a processivity factor. Information

Substance Name: Endonucleases

Registry Number: EC 3.1.-

Grant and Affiliation Information for Domains in the XPA protein important in its role as a processivity factor.

AFFILIATION: Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: R01 ES011298-03

ACRONYM: ES

MEDLINETA: Biochem Biophys Res Commun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Domains in the XPA protein important in its role as a processivity factor Related Publications

• Active Galpha(q) subunits and M3 acetylcholine receptors promote distinct modes of association of RGS2 with the plasma membrane.
• Androgen metabolites in bovine follicular fluid.
• Anxiety, depression and coping strategies in post-hysterectomy Chinese women prior to discharge.
• Asymmetric ERM activation at the Schwann cell process tip is required in axon-associated motility.
• Changes in heart rate recovery in response to acute changes in training load.
• Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis.
• Domains in the XPA protein important in its role as a processivity factor.
• Factors associated with menstrual dysfunction and self-reported bone stress injuries in female runners in the ultra- and half-marathons of the Two Oceans.
• Gain is not always good.
• HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP.
• Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis.
• Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model.
• In vitro pharmacological characterisation of a novel cyclic nociceptin/orphanin FQ analogue c[Cys(7,10)]N/OFQ(1-13)NH (2).
• Induction of promyelocytic leukemia (PML) oncogenic domains (PODs) by papillomavirus.
• Infectious disease among enslaved African Americans at Eaton's Estate, Warren County, North Carolina, ca. 1830-1850.
• Metabolic consequences of exercise-induced muscle damage.
• Molecular evolution of hemojuvelin and the repulsive guidance molecule family.
• Multiple sites of exposure in an outbreak of ornithosis in workers at a poultry abattoir and farm.
• Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.
• Prevalence and clinical phenotype of the p.Val226Met glucokinase gene mutation in French Canadians in Quebec, Canada.
• Rapid activation of inwardly rectifying potassium channels by immobile G-protein-coupled receptors.
• Some G protein heterotrimers physically dissociate in living cells.
• Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk?
• The Effect Of Fat-adaptation Followed By Carbohydrate-loading On Ultra-endurance Cycling Performance: 803: June 1 8:15 AM - 8:30 AM.
• The effect of bone marrow transplants on DNA profiles; a case example.
• The neuronal noradrenaline transporter, anxiety and cardiovascular disease.
• Vitamin D deficiency.
• Workshop of experts: definition, recognition, assessment, and alleviation of animal distress in the laboratory.
• [In Process Citation]
• alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.