Domain interplay concept in animal models of neuropsychiatric disorders: A new strategy for high-throughput neurophenotyping research.

Domain interplay concept in animal models of neuropsychiatric disorders: A new strategy for high-throughput neurophenotyping research. Research Abstract Details 

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Domain interplay concept in animal models of neuropsychiatric disorders: A new strategy for high-throughput neurophenotyping research. Abstract Text:

Allan V Kalueff,Renee F Ren-Patterson,Justin L Laporte,Dennis L Murphy,

Genetic and environmental factors play a key role in psychiatric disorders. While some disorders display exceptionally high heritability, others show genexexperiencexpersonality interactions, contributing complexity to psychiatric phenotypes. As some brain disorders frequently overlap and co-occur (representing a continuum or spectrum of phenomena), modern psychiatry is shifting from "artificial" heterogeneity to the recognition of common elements in the pathogenesis of emotional, personality and behavioral disorders. Genetic animal models of these disorders represent an important direction of research, and are widely used to explore the role of different genes in brain mechanisms. Several concepts (such as endophenotypes, genexenvironment interactions, and cross-species trait genetics) have been suggested for animal experimentation in this field. Here we develop a new concept based on targeting the complex interplay between different behavioral domains, meant to foster high-throughput phenotyping and integrative modeling of psychiatric disorders.

Domain interplay concept in animal models of neuropsychiatric disorders: A new strategy for high-throughput neurophenotyping research. Publishing Authors By Initials

AV Kalueff,RF Ren-Patterson,JL Laporte,DL Murphy,

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Domain interplay concept in animal models of neuropsychiatric disorders: A new strategy for high-throughput neurophenotyping research. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Behavioural brain research

VOLUME: 188

Page Numbers: 243-9

Journal Abbreviation: Behav. Brain Res.

ISSN: 0166-4328

DAY: 22

MONTH: 11

YEAR: 2007

Domain interplay concept in animal models of neuropsychiatric disorders: A new strategy for high-throughput neurophenotyping research. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Domain interplay concept in animal models of neuropsychiatric disorders: A new strategy for high-throughput neurophenotyping research.

AFFILIATION: Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health, 10 Center Dr. MSC 1264, Bethesda, MD 20892-1264, USA.

Country: Netherlands

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MEDLINETA: Behav Brain Res

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