Dok-1 is a positive regulator of IL-4 signalling and IgE response.

Dok-1 is a positive regulator of IL-4 signalling and IgE response. Research Abstract Details 

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Dok-1 is a positive regulator of IL-4 signalling and IgE response. Abstract Text:

Akane Inoue,Tomoharu Yasuda,Tadashi Yamamoto,Yuji Yamanashi,Akane Inoue,Tomoharu Yasuda,Tadashi Yamamoto,Yuji Yamanashi,

Interleukin-4 (IL-4) plays an essential role in the control of humoral immunity by regulating lymphocyte proliferation and differentiation, including the T helper type 2 lineage commitment of CD4(+) T cells as well as the isotype switching to IgE in B cells. The adaptor protein Dok-1 is known to have an essential role in the negative regulation of a variety of cytokine signalling events. However, here we have found that the loss of Dok-1 impaired the proliferative response of CD4(+) T cells and B cells to IL-4. Conversely, the forced expression of Dok-1 in the myeloid cell line 32D augmented the IL-4-induced proliferation, indicating a positive role for Dok-1. Tyrosine phosphorylation, and thereby the activation of Stat6 and IRS-2, is critical for IL-4 signalling; however, only the activation of Stat6, not the IRS-2-dependent phosphorylation of Akt, was perturbed in Dok-1-deficient cells stimulated with IL-4. Furthermore, mice lacking Dok-1 showed an impaired IgE response to thymus-dependent antigen. Thus, Dok-1 is a positive regulator of IL-4 signalling and IgE response.

Dok-1 is a positive regulator of IL-4 signalling and IgE response. Publishing Authors By Initials

A Inoue,T Yasuda,T Yamamoto,Y Yamanashi,A Inoue,T Yasuda,T Yamamoto,Y Yamanashi,

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Dok-1 is a positive regulator of IL-4 signalling and IgE response. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 142

Page Numbers: 257-63

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 7

MONTH: 09

YEAR: 2007

Dok-1 is a positive regulator of IL-4 signalling and IgE response. Information

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LANGUAGE: eng

NlmUniqueID: 376600

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Grant and Affiliation Information for Dok-1 is a positive regulator of IL-4 signalling and IgE response.

AFFILIATION: Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8510.

Country: Japan

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MEDLINETA: J Biochem (Tokyo)

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