Dog ownership enhances symptomatic responses to air pollution in children with asthma.

Dog ownership enhances symptomatic responses to air pollution in children with asthma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Dog ownership enhances symptomatic responses to air pollution in children with asthma. Abstract Text:

Rob McConnell,Kiros Berhane,Jassy Molitor,Frank Gilliland,Nino ,Peter S Thorne,Duncan Thomas,W James Gauderman,Edward Avol,Fred Lurmann,Edward Rappaport,Michael Jerrett,John M Peters,

BACKGROUND: Experimental data suggest that asthma exacerbation by ambient air pollutants is enhanced by exposure to endotoxin and allergens; however, there is little supporting epidemiologic evidence. METHODS: We evaluated whether the association of exposure to air pollution with annual prevalence of chronic cough, phlegm production, or bronchitis was modified by dog and cat ownership (indicators of allergen and endotoxin exposure). The study population consisted of 475 Southern California children with asthma from a longitudinal cohort of participants in the Children's Health Study. We estimated average annual ambient exposure to nitrogen dioxide, ozone, particulate matter < 10, 2.5, and 10-2.5 microm in aerodynamic diameter (PM10, PM2.5, and PM10-2.5, respectively), elemental and organic carbon, and acid vapor from monitoring stations in each of the 12 study communities. Multivariate models were used to examine the effect of yearly variation of each pollutant. Effects were scaled to the variability that is common for each pollutant in representative communities in Southern California. RESULTS: Among children owning a dog, there were strong associations between bronchitic symptoms and all pollutants examined. Odds ratios ranged from 1.30 per 4.2 microg/m3 for PM10-2.5 [95% confidence interval (CI), 0.91-1.87) to 1.91 per 1.2 microg/m3 for organic carbon (95% CI, 1.34-2.71). Effects were somewhat larger among children who owned both a cat and dog. There were no effects or small effects with wide CIs among children without a dog and among children who owned only a cat. CONCLUSION: Our results suggest that dog ownership, a source of residential exposure to endotoxin, may worsen the relationship between air pollution and respiratory symptoms in asthmatic children.

Dog ownership enhances symptomatic responses to air pollution in children with asthma. Publishing Authors By Initials

R McConnell,K Berhane,J Molitor,F Gilliland,N ,PS Thorne,D Thomas,WJ Gauderman,E Avol,F Lurmann,E Rappaport,M Jerrett,JM Peters,

For similar respiratory tract diseases research abstracts see: respiratory tract diseases research

PUBMED ID PMID:

MEDLINE DATE:

Dog ownership enhances symptomatic responses to air pollution in children with asthma. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Environmental health perspectives

VOLUME: 114

Page Numbers: 1910-5

Journal Abbreviation: Environ. Health Perspect.

ISSN: 0091-6765

DAY: 3

MONTH: Dec

YEAR: 2006

Dog ownership enhances symptomatic responses to air pollution in children with asthma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 330411

Dog ownership enhances symptomatic responses to air pollution in children with asthma. Keywords Mesh Terms:

KEYWORDS: Respiratory Tract Diseases

MESH TERMS: etiology

Chemical & Substance for Abstract: Dog ownership enhances symptomatic responses to air pollution in children with asthma. Information

Substance Name: Nitrogen Dioxide

Registry Number: 10102-44-0

Grant and Affiliation Information for Dog ownership enhances symptomatic responses to air pollution in children with asthma.

AFFILIATION: Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA. rmcconne@usc.edu

Country: United States

AGENCY: United States NHLBI

GRANT: 5R01 HL061768

ACRONYM: HL

MEDLINETA: Environ Health Perspect

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Dog ownership enhances symptomatic responses to air pollution in children with asthma Related Publications

• A mouse TRAPP-related protein is involved in pigmentation.
• Assessment of the factors affecting the volume of fetally derived tissue in the bovine placentome.
• Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine.
• Catalytic receptors.
• Cell-surface transmitter transporters.
• Commentary left and right in classical Greece and Italy.
• Cooperative learning: a new application of problem-based learning in mental health training.
• De novo malignancies following liver transplantation: a case-control study with long-term follow-up.
• Determination of etoposide (VP16-213) and teniposide (VM-26) in serum by high-performance liquid chromatography with electrochemical detection.
• Dog ownership enhances symptomatic responses to air pollution in children with asthma.
• Fe(I)-mediated reductive cleavage and coupling of CO(2): an Fe(II)(mu-O, mu-CO)Fe(II) core.
• Functional characterization of the rice kaurene synthase-like gene family.
• Guide to Receptors and Channels, 2nd edition (2007 Revision).
• Immune epitope mapping in the post-genomic era: lessons for vaccine development.
• Long-term consequences of pain in human neonates.
• Nanoscopic medicine: the next frontier.
• Neuromodulation for the treatment of refractory interstitial cystitis.
• Novel model of antigen-specific induction of bile duct injury.
• Nuclear receptors.
• On the feasibility of N2 fixation via a single-site FeI/FeIV cycle: Spectroscopic studies of FeI(N2)FeI, FeIV[triple bond]N, and related species.
• Polymorphism analysis of six selenoprotein genes: support for a selective sweep at the glutathione peroxidase 1 locus (3p21) in Asian populations.
• Prospective study of air pollution and bronchitic symptoms in children with asthma.
• Pseudotetrahedral manganese complexes supported by the anionic tris(phosphino)borate ligand [PhBP(iPr)3].
• Regular smoking and asthma incidence in adolescents.
• Separation of ribonucleotides, deoxynucleotides, cyclic nucleotides and deoxycyclic nucleotides by reversed-phase high-performance liquid chromatography.
• Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor.
• Skeletal muscle fiber type comparison of pyruvate dehydrogenase phosphatase activity and isoform expression in fed and food-deprived rats.
• Synergistic inhibition of SARS-coronavirus replication by type I and type II IFN.
• The challenge of managing body weight in the modern world.
• Usefulness of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with a residual structural abnormality after definitive treatment for squamous cell carcinoma of the head and neck.