Does electrocardiographic Q wave burden predict the extent of scarring or hibernating myocardium as quantified by positron emission tomography?

Does electrocardiographic Q wave burden predict the extent of scarring or hibernating myocardium as quantified by positron emission tomography? Research Abstract Details 

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Does electrocardiographic Q wave burden predict the extent of scarring or hibernating myocardium as quantified by positron emission tomography? Abstract Text:

Karthikeyan Ananthasubramaniam,Benjamin J W Chow,Terrence D Ruddy,Robert deKemp,Ross A Davies,Jean DaSilva,Rob S B Beanlands,

BACKGROUND: The extent of Q wave 'burden' on electrocardiograms (ECGs) has not been correlated with the extent of scarring and hibernation as determined quantitatively by positron emission tomography (PET). OBJECTIVE: A retrospective study was performed to identify if ECG Q wave burden predicts the extent of scarring or mismatch (hibernating myocardium) as defined by rubidium-82/F-18 fluorodeoxyglucose PET viability imaging. PATIENTS AND METHODS: Eighty-three consecutive patients with coronary artery disease undergoing rubidium-82/F-18 fluoro-deoxyglucose viability imaging (mean age 67.9+/-11 years, with a mean ejection fraction of 27+/-7%) formed the study population. Resting ECG was interpreted for the presence or absence of Q waves using standard ECG criteria for Q wave myocardial infarction. Patients were divided into two groups based on their Q wave burden on ECG (small to moderate scar: zero to four Q waves; large scar: five or more Q waves). Automated analysis was used to calculate the extent of scarring and mismatch (hibernating myocardium) on PET as a percentage of left ventricular myocardium. Mean PET scar and mismatch scores were calculated for the two groups. RESULTS: The mean PET scar scores were significantly different between the small to moderate ECG scar group (13.9+/-7.3% of the left ventricle) and the large scar group (20.6+/-8.1% of the left ventricle; P=0.001). The mismatch scores for the small to moderate scar group (4.6+/-2.8%) were not significantly different from those of the large scar group (4.05+/-2.8%; P=0.7). CONCLUSIONS: ECG Q wave 'burden' was associated with the presence of scars as defined by PET but did not accurately predict the amount of hibernating myocardium.

Does electrocardiographic Q wave burden predict the extent of scarring or hibernating myocardium as quantified by positron emission tomography? Publishing Authors By Initials

K Ananthasubramaniam,BJ Chow,TD Ruddy,R deKemp,RA Davies,J DaSilva,RS Beanlands,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: tissue survival research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: tissue survival research

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Does electrocardiographic Q wave burden predict the extent of scarring or hibernating myocardium as quantified by positron emission tomography? Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Canadian journal of cardiology

VOLUME: 21

Page Numbers: 51-6

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ISSN: 1916-7075

DAY: 3

MONTH: Jan

YEAR: 2005

Does electrocardiographic Q wave burden predict the extent of scarring or hibernating myocardium as quantified by positron emission tomography? Information

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LANGUAGE: eng

NlmUniqueID: 8510280

Does electrocardiographic Q wave burden predict the extent of scarring or hibernating myocardium as quantified by positron emission tomography? Keywords Mesh Terms:

KEYWORDS: Tissue Survival

MESH TERMS: pathology

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Grant and Affiliation Information for Does electrocardiographic Q wave burden predict the extent of scarring or hibernating myocardium as quantified by positron emission tomography?

AFFILIATION: National Cardiac PET Centre, Department of Medicine, University of Ottawa Heart Institute, Ontario.

Country: Canada

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MEDLINETA: Can J Cardiol

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