Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment?

Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment? Research Abstract Details 

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Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment? Abstract Text:

H Schleusener,J Schwander,G Holl,K Badenhoop,J Hensen,R Finke,G Schernthaner,W R Mayr,P Kotulla,

In patients with Graves' hyperthyroidism, the relapse rate after antithyroid drug treatment is in the range of about 30-70%. Different attempts have been made to obtain criteria for the prediction of the clinical outcome after drug therapy, especially HLA-DR typing and measurement of TSH receptor antibodies. So far, very conflicting results have been reported. This is not surprising in view of the many genetically controlled and environmental factors that play a role in the pathogenesis of this disease. Moreover, most reports are based on retrospective studies with a relatively small number of patients. Our own data, obtained in a prospective multicenter study, yield strong evidence against the relevance of HLA-DR3 typing (n = 187, sensitivity = 0.38, specificity = 0.67) or measurement of TSH receptor antibodies at the end of therapy (n = 269, sensitivity = 0.49, specificity = 0.72) for the prediction of the clinical course after drug treatment.

Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment? Publishing Authors By Initials

H Schleusener,J Schwander,G Holl,K Badenhoop,J Hensen,R Finke,G Schernthaner,WR Mayr,P Kotulla,

For similar endocrine system diseases: thyroid diseases research abstracts see: endocrine system diseases: thyroid diseases research

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Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment? Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta endocrinologica. Supplementum

VOLUME: 281

Page Numbers: 318-24

Journal Abbreviation:

ISSN: 0300-9750

DAY: 12

MONTH: 02

YEAR: 1987

Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment? Information

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LANGUAGE: eng

NlmUniqueID: 370313

Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment? Keywords Mesh Terms:

KEYWORDS: Thyroid Diseases

MESH TERMS: immunology

Chemical & Substance for Abstract: Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment? Information

Substance Name: Receptors, Thyrotropin

Registry Number: 0

Grant and Affiliation Information for Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment?

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Country: DENMARK

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MEDLINETA: Acta Endocrinol Suppl (Copenh)

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Do HLA-DR-typing and measurement of TSH-receptor antibodies help in the prediction of the clinical course of Graves' thyrotoxicosis after antithyroid drug treatment? Related Publications

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