DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells.

DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Research Abstract Details 

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DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Abstract Text:

Mattias Carlsten,Niklas K , Norell,Yenan Bryceson,Thorbald van Hall,Bettina C Baumann,Mikael Hanson,Kjell Schedvins,Rolf Kiessling,Hans-Gustaf Ljunggren,Karl-Johan Malmberg,

Although natural killer (NK) cells are well known for their ability to kill tumors, few studies have addressed the interactions between resting (nonactivated) NK cells and freshly isolated human tumors. Here, we show that human leukocyte antigen class I(low) tumor cells isolated directly from patients with advanced ovarian carcinoma trigger degranulation by resting allogeneic NK cells. This was paralleled by induction of granzyme B and caspase-6 activities in the tumor cells and significant tumor cell lysis. Ovarian carcinoma cells displayed ubiquitous expression of the DNAX accessory molecule-1 (DNAM-1) ligand PVR and sparse/heterogeneous expression of the NKG2D ligands MICA/MICB and ULBP1, ULBP2, and ULBP3. In line with the NK receptor ligand expression profiles, antibody-mediated blockade of activating receptor pathways revealed a dominant role for DNAM-1 and a complementary contribution of NKG2D signaling in tumor cell recognition. These results show that resting NK cells are capable of directly recognizing freshly isolated human tumor cells and identify ovarian carcinoma as a potential target for adoptive NK cell-based immunotherapy.

DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Publishing Authors By Initials

M Carlsten,NK ,H Norell,Y Bryceson,T van Hall,BC Baumann,M Hanson,K Schedvins,R Kiessling,HG Ljunggren,KJ Malmberg,

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic research

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DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 1317-25

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 1

MONTH: Feb

YEAR: 2007

DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Keywords Mesh Terms:

KEYWORDS: Receptors, Immunologic

MESH TERMS: immunology

Chemical & Substance for Abstract: DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Information

Substance Name: Granzymes

Registry Number: EC 3.4.21.-

Grant and Affiliation Information for DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells.

AFFILIATION: Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.

Country: United States

AGENCY: United States NCI

GRANT: CA 102280

ACRONYM: CA

MEDLINETA: Cancer Res

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