DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC.

DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Research Abstract Details 

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DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Abstract Text:

Yongli Zhang,Corey L Smith,Anjanabha Saha,Stephan W Grill,Shirley Mihardja,Steven B Smith,Bradley R Cairns,Craig L Peterson,Carlos Bustamante,

ATP-dependent chromatin-remodeling complexes (remodelers) modulate gene transcription by regulating the accessibility of highly packaged genomic DNA. However, the molecular mechanisms involved at the nucleosomal level in this process remain controversial. Here, we monitor the real-time activity of single ySWI/SNF or RSC complexes on single, stretched nucleosomal templates under tensions above 1 pN forces. We find that these remodelers can translocate along DNA at rates of approximately 13 bp/s and generate forces up to approximately 12 pN, producing DNA loops of a broad range of sizes (20-1200 bp, average approximately 100 bp) in a nucleosome-dependent manner. This nucleosome-specific activity differs significantly from that on bare DNA observed under low tensions and suggests a nucleosome-remodeling mechanism through intranucleosomal DNA loop formation. Such loop formation may provide a molecular basis for the biological functions of remodelers.

DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Publishing Authors By Initials

Y Zhang,CL Smith,A Saha,SW Grill,S Mihardja,SB Smith,BR Cairns,CL Peterson,C Bustamante,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Molecular cell

VOLUME: 24

Page Numbers: 559-68

Journal Abbreviation: Mol. Cell

ISSN: 1097-2765

DAY: 17

MONTH: Nov

YEAR: 2006

DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9802571

DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC.

AFFILIATION: Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM60415

ACRONYM: GM

MEDLINETA: Mol Cell

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