DNA replication initiation: mechanisms and regulation in bacteria.

DNA replication initiation: mechanisms and regulation in bacteria. Research Abstract Details 

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DNA replication initiation: mechanisms and regulation in bacteria. Abstract Text:

Melissa L Mott,James M Berger,

In all organisms, multi-subunit replicases are responsible for the accurate duplication of genetic material during cellular division. Initiator proteins control the onset of DNA replication and direct the assembly of replisomal components through a series of precisely timed protein-DNA and protein-protein interactions. Recent structural studies of the bacterial protein DnaA have helped to clarify the molecular mechanisms underlying initiator function, and suggest that key structural features of cellular initiators are universally conserved. Moreover, it appears that bacteria use a diverse range of regulatory strategies dedicated to tightly controlling replication initiation; in many cases, these mechanisms are intricately connected to the activities of DnaA at the origin of replication. This Review presents an overview of both the mechanism and regulation of bacterial DNA replication initiation, with emphasis on the features that are similar in eukaryotic and archaeal systems.

DNA replication initiation: mechanisms and regulation in bacteria. Publishing Authors By Initials

ML Mott,JM Berger,

For similar replication origin research abstracts see: replication origin research

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DNA replication initiation: mechanisms and regulation in bacteria. Journal Published:

PUBLICATION TYPE: Review

Journal: Nature reviews. Microbiology

VOLUME: 5

Page Numbers: 343-54

Journal Abbreviation:

ISSN: 1740-1534

DAY: 3

MONTH: May

YEAR: 2007

DNA replication initiation: mechanisms and regulation in bacteria. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101190261

DNA replication initiation: mechanisms and regulation in bacteria. Keywords Mesh Terms:

KEYWORDS: Replication Origin

MESH TERMS: metabolism

Chemical & Substance for Abstract: DNA replication initiation: mechanisms and regulation in bacteria. Information

Substance Name: DnaA protein, Bacteria

Registry Number: 0

Grant and Affiliation Information for DNA replication initiation: mechanisms and regulation in bacteria.

AFFILIATION: Department of Molecular and Cell Biology, Quantitative Biology Institute, University of California, Berkeley, 237 Hildebrand Hall #3220, California 94720-3220, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM071747

ACRONYM: GM

MEDLINETA: Nat Rev Microbiol

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