DNA polymerase-mediated DNA synthesis on a TNA template.

DNA polymerase-mediated DNA synthesis on a TNA template. Research Abstract Details 

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DNA polymerase-mediated DNA synthesis on a TNA template. Abstract Text:

John C Chaput,Justin K Ichida,Jack W Szostak,

TNA, or threose nucleic acid, is capable of Watson-Crick base pairing with DNA, RNA, and TNA; coupled with its chemical simplicity, this suggests that TNA is a possible progenitor of RNA. As an initial step toward developing the molecular tools necessary to investigate the functional capabilities of TNA by in vitro selection, we have screened a variety of DNA polymerases for activity on a TNA template. We report that despite having a repeating unit that is one atom shorter than that of DNA, several polymerases showed surprisingly good ability to copy limited stretches of TNA.

DNA polymerase-mediated DNA synthesis on a TNA template. Publishing Authors By Initials

JC Chaput,JK Ichida,JW Szostak,

For similar carbohydrates: monosaccharides: tetroses research abstracts see: carbohydrates: monosaccharides: tetroses research

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DNA polymerase-mediated DNA synthesis on a TNA template. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 856-7

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 29

MONTH: Jan

YEAR: 2003

DNA polymerase-mediated DNA synthesis on a TNA template. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

DNA polymerase-mediated DNA synthesis on a TNA template. Keywords Mesh Terms:

KEYWORDS: Tetroses

MESH TERMS: chemistry

Chemical & Substance for Abstract: DNA polymerase-mediated DNA synthesis on a TNA template. Information

Substance Name: DNA-Directed DNA Polymerase

Registry Number: EC 2.7.7.7

Grant and Affiliation Information for DNA polymerase-mediated DNA synthesis on a TNA template.

AFFILIATION: Howard Hughes Medical Institute, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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