DNA ploidy analysis of borderline epithelial ovarian tumours.

DNA ploidy analysis of borderline epithelial ovarian tumours. Research Abstract Details 

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DNA ploidy analysis of borderline epithelial ovarian tumours. Abstract Text:

S Lodhi,S Najam,S Pervez,

OBJECTIVE: Borderline epithelial ovarian tumours not uncommonly pose a great difficulty to surgical pathologists as morphologically they may show very similar features as those of malignant epithelial tumours except invasion. However it is important to separate these from their invasive counterparts because of their superior prognosis. Recently, attention has been focussed on the prognostic value of flow cytometric analysis of DNA ploidy in borderline epithelial ovarian tumours. The purpose of this study is to investigate whether flow cytometric analysis of cellular DNA content acts as a useful adjunct to the histopathological diagnosis of borderline malignancy. MATERIALS AND METHODS: Fifteen histologically confirmed borderline serous epithelial tumours of the ovary were selected. Samples were analyzed on a FACScan flow cytometer using the software MODFIT. A total of 10,000 nuclei were counted each time. RESULTS: The mean CV for the 15 cases was 3.67 (Range 2.4-5.0). In the DNA histograms a diploid sample was defined as one that had a single Go/Gl peak. An aneuploid tumour was defined as one that displayed an additional distinct peak. All 15 cases of borderline serous epithelial tumours showed a diploid stemline with DNA index between 0.9-1.10. CONCLUSION: This study suggests that aneuploidy if ever demonstrated in histologically confirmed borderline tumours should prompt extensive sampling of the tumour and a close follow up.

DNA ploidy analysis of borderline epithelial ovarian tumours. Publishing Authors By Initials

S Lodhi,S Najam,S Pervez,

For similar genetic phenomena: ploidies research abstracts see: genetic phenomena: ploidies research

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DNA ploidy analysis of borderline epithelial ovarian tumours. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: JPMA. The Journal of the Pakistan Medical Associat

VOLUME: 50

Page Numbers: 349-51

Journal Abbreviation:

ISSN: 0030-9982

DAY: 12

MONTH: Oct

YEAR: 2000

DNA ploidy analysis of borderline epithelial ovarian tumours. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7501162

DNA ploidy analysis of borderline epithelial ovarian tumours. Keywords Mesh Terms:

KEYWORDS: Ploidies

MESH TERMS: genetics

Chemical & Substance for Abstract: DNA ploidy analysis of borderline epithelial ovarian tumours. Information

Substance Name: DNA, Neoplasm

Registry Number: 0

Grant and Affiliation Information for DNA ploidy analysis of borderline epithelial ovarian tumours.

AFFILIATION: Department of Pathology, Aga Khan University Hospital, Karachi.

Country: PAKISTAN

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MEDLINETA: J Pak Med Assoc

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