DLC-1:a Rho GTPase-activating protein and tumour suppressor.

DLC-1:a Rho GTPase-activating protein and tumour suppressor. Research Abstract Details 

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DLC-1:a Rho GTPase-activating protein and tumour suppressor. Abstract Text:

Marian E Durkin,Bao-Zhu Yuan,Xiaoling Zhou,Drazen B Zimonjic,Douglas R Lowy,Snorri S Thorgeirsson,Nicholas C Popescu,Marian E Durkin,Bao-Zhu Yuan,Xiaoling Zhou,Drazen B Zimonjic,Douglas R Lowy,Snorri S Thorgeirsson,Nicholas C Popescu,Marian E Durkin,Bao-Zhu Yuan,Xiaoling Zhou,Drazen B Zimonjic,Douglas R Lowy,Snorri S Thorgeirsson,Nicholas C Popescu,

The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrates a role for DLC-1 as a bona fide tumour suppressor gene in different types of human cancer. Loss of DLC-1 expression mediated by genetic and epigenetic mechanisms has been associated with the development of many human cancers, and restoration of DLC-1 expression inhibited the growth of tumour cells in vivo and in vitro. Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors. This review presents the current status of progress in understanding the biological functions of DLC-1 and its relatives and their roles in neoplasia.

DLC-1:a Rho GTPase-activating protein and tumour suppressor. Publishing Authors By Initials

ME Durkin,BZ Yuan,X Zhou,DB Zimonjic,DR Lowy,SS Thorgeirsson,NC Popescu,ME Durkin,BZ Yuan,X Zhou,DB Zimonjic,DR Lowy,SS Thorgeirsson,NC Popescu,ME Durkin,BZ Yuan,X Zhou,DB Zimonjic,DR Lowy,SS Thorgeirsson,NC Popescu,

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DLC-1:a Rho GTPase-activating protein and tumour suppressor. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cellular and molecular medicine

VOLUME: 11

Page Numbers: 1185-207

Journal Abbreviation: J. Cell. Mol. Med.

ISSN: 1582-1838

DAY: 5

MONTH: 11

YEAR: 2007

DLC-1:a Rho GTPase-activating protein and tumour suppressor. Information

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LANGUAGE: eng

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Grant and Affiliation Information for DLC-1:a Rho GTPase-activating protein and tumour suppressor.

AFFILIATION: Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Country: Romania

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MEDLINETA: J Cell Mol Med

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